Results 231 to 240 of about 22,116 (307)

Differential treatment of individuals with mental health conditions in high-consequence decision-making: a comparison of policy on advance directives and assisted suicide in three European countries. [PDF]

Front Psychiatry
Gloeckler S, Scholten M, Biller-Andorno N.   +2 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Research Advance Directives: Ethical Implications for Persons with Alzheimer's Disease, and for the Families of Elderly Dementia Patients. [PDF]

J Law Med Ethics
Hart DE.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Advance directives in amyotrophic lateral sclerosis - a systematic review and meta-analysis. [PDF]

BMC Palliat Care
Mangal AL, Mücke M, Rolke R, Appelmann I.   +3 more
europepmc   +1 more source

End-of-life decision-making and changing preferences in patients with a left ventricular assist device for destination therapy: insights from advance directives in Japan. [PDF]

J Artif Organs
Izumida T, Amiya E, Hatano M, Ishida J, Kanno M, Shimada A, Endo M, Ando M, Kimura M, Shimada S, Ono M, Takeda N.   +11 more
europepmc   +1 more source

The instrumental value of advance directives: lesson learned from the COVID-19 pandemic for policymaking. [PDF]

Res Health Serv Reg
Stock E, Nickel CH, Elger BS, Martani A.
europepmc   +1 more source

Advance directives in the emergency department-a systematic review of the status quo. [PDF]

BMC Health Serv Res
Weber V, Hübner A, Pflock S, Schamberger L, Somasundaram R, Boehm L, Bauer W, Diehl-Wiesenecker E.   +7 more
europepmc   +1 more source