Results 61 to 70 of about 181,542 (334)

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Prevalence, clinical impact and associated patient-centred outcomes of advance directives in Swiss intensive care units: Results from the retrospective ADVISE Study

Swiss Medical Weekly
STUDY AIMS: Data on the usefulness of advance directives for end-of-life decision-making in intensive care units (ICUs) are scarce. The primary aim of the present study was to investigate the prevalence of advance directives in patients of two Swiss ...
Sira Maria Baumann, Dominik Vock, Paulina S. C. Kliem, Simon A. Amacher, Yasmin Erne, Pascale Grzonka, Sebastian Berger, Martin Lohri, Sabina Hunziker, Caroline E. Gebhard, Mathias Nebiker, Luca Cioccari, Raoul Sutter   +12 more
doaj   +1 more source

Why have Advance Directives failed in Spain?

BMC Medical Ethics, 2020
Background In Spain, there has been great effort by lawmakers to put Advance Directives (ADs) into practice since 2002. At the same time, the field of bioethics has been on the rise, a discipline that has spurred debate on the right of patients to ...
Benjamín Herreros, María Benito, Pablo Gella, Emanuele Valenti, Beatriz Sánchez, Tayra Velasco   +5 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Novel approach to advance directive training: Hospice and palliative care fellow led workshop feasible and effective in increasing confidence in end of life conversations.

PLoS ONE
Despite the benefits of Advance directives, approximately only 1 in 3 U.S adults have documented advance directives. In medical school and residency, learners are often not taught or given very brief information on conducting end-of-life planning ...
Chelsea Chang, Jose Cano, Juan Lopez-Alvarenga, Josenny Rodriguez-Paez, Sonya Montes, Rosa White, Meghana Rao   +6 more
doaj   +1 more source

Advance directives and consent to organ donation in seven university hospitals in North Rhine–Westphalia [PDF]

, 2023
Jan Sönke Englbrecht, Daniel Schrader, Holger Kraus, Melanie Schäfer, Dirk Schedler, Friedhelm Bach, Martin Söhle   +6 more
openalex   +1 more source

Making an advance directive [PDF]

BMJ, 1995
The introduction in Britain of advance directives--which allow a person to state in advance of becoming incompetent that they wish to take part in treatment decisions when no longer mentally competent--has now been advocated by the medical and legal establishments.
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Medisinsk behandling og bindende forhåndsønsker- Noe for Norge? : En oversikt og diskusjon om verdien av forhåndsønsker og pasientens rett til å oppnevne stedfortredende beslutningstaker [PDF]

, 2009
A patient’s opportunity to affect and participate in decision-making with regard to their own medical care is considered important. Most patients want some control over their medical care, including or even especially, when they are too sick to ...
Løitegård, Kjetil
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source