Results 101 to 110 of about 410,880 (314)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Polycomb proteins and breast cancer

, 2013
In the Western world, breast cancer is the most frequent malignancy in women and still the leading cause of cancer related deaths, therefore, a better understanding of the disease is needed.
Fedele, Vita
core  

Understanding the factors that influence breast reconstruction decision making in Australian women [PDF]

, 2015
Background Breast reconstruction is safe and improves quality of life. Despite this, many women do not undergo breast reconstruction and the reasons for this are poorly understood.
Baghdikian, Nairy, Somogyi, Ron Barry, Stephenson, John, Morrison, Wayne A, Edward, Karen Leigh, Edward, Karen-Leigh, Stephenson, J, Webb, Angela, Morrison, Wayne   +8 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials [PDF]

, 2010
Background: We conducted a systematic review and meta-analysis to clarify the risk of early and late cardiotoxicity of anthracycline agents in patients treated for breast or ovarian cancer, lymphoma, myeloma or sarcoma.Methods: Randomized controlled ...
Gill Levitt, Smith Lesley A, Cornelius Victoria R, Canney Peter, Levitt, G, Smith, Lesley A., Canney, P, Verrill, Mark, Lesley A Smith, Cornelius, Victoria, Verrill Mark, Plummer, CJ, Verrill, M, Peter Canney, Cornelius, VR, Lesley, A. Smith, Canney, Peter, Plummer, Christopher J., Victoria R Cornelius, Plummer Christopher J, Alison Jones, Smith, LA, Christopher J Plummer, Jones, Alison, Jones Alison, Jones, A, Levitt Gill, Levitt, Gill, Cornelius, Victoria R., Mark Verrill   +29 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Identification and validation of oncologic miRNA biomarkers for Luminal A-like breast cancer

, 2014
Introduction: Breast cancer is a common disease with distinct tumor subtypes phenotypically characterized by ER and HER2/neu receptor status. MiRNAs play regulatory roles in tumor initiation and progression, and altered miRNA expression has been ...
Wall, D, Sweeney Karl J., Michael J Kerin, Kerin Michael J., Graham Ball, Miller Nicola, Nicola Miller (84418), Ball, G, Wall Deirdre, McDermott Ailbhe M., McDermott, AM, Ailbhe M. McDermott (114313), Kerin, MJ, Deirdre Wall, Michael J. Kerin (114334), Nicola Miller, Deirdre Wall (114317), Martyn Lorcan M., Karl J. Sweeney (237846), Lorcan M Martyn, Miller, N, Ball Graham, Sweeney, KJ, Lorcan M. Martyn (517942), Graham Ball (72613), Martyn, LM, Ailbhe M McDermott, Karl J Sweeney   +27 more
core   +1 more source

Pathological Features of Breast Cancer seen in Northwestern Tanzania: A Nine Years Retrospective Study. [PDF]

, 2011
Breast cancer is more common in Western Countries compared to African populations. However in African population, it appears that the disease tends to be more aggressive and occurring at a relatively young age at the time of presentation. The aim of this
Chalya Philipo L, Jackson Kahima J, Jackson, Kahima J, Rambau Peter F, Chalya, Philipo L, Manyama, Mange M, Mange M Manyama, Manyama Mange M, Peter F Rambau, Philipo L Chalya, Rambau, Peter F, Kahima J Jackson   +11 more
core   +1 more source

Leucine-rich repeat neuronal 1 as a prognostic indicator and functional modulator in breast cancer

Frontiers in Oncology
IntroductionAdvanced breast cancer remains a major therapeutic challenge with high mortality rates. While leucine-rich repeat (LRR) proteins play roles in various cancers including breast cancer, their specific functions are still underexplored.
Jiaxin Wang, Jiaxin Wang, Xiqian Zhou, Xiqian Zhou, Ding Ping, Ding Ping, Meiling Lu, Yue Zhang, Hongming Song, Junyong Zhao, Junyong Zhao, Dengfeng Li, Dengfeng Li   +12 more
doaj   +1 more source