Results 111 to 120 of about 410,880 (314)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Interventions to improve exercise behaviour in sedentary people living with and beyond cancer: a systematic review. [PDF]

, 2014
To systematically review the effects of interventions to improve exercise behaviour in sedentary people living with and beyond ...
Thaha, MA, Steed, L., K A Robb, Homer, Kate, Thaha, M.A., Rosario, DJ, Bourke, Liam, Robb, Karen, Robb, KA, M A Thaha, Saxton, John, Taylor, SJ, Taylor, S.J.C., S J C Taylor, Steed, Liz, Saxton, J.M., D J Rosario, Rosario, D.J., Robb, K.A., K E Homer, J M Saxton, Saxton, JM, Taylor, Stephanie, L Bourke, Bourke, L, Thaha, Mohamed, Rosario, Derek J., L Steed, Homer, K.E., Taylor, SJC, Homer, KE, Steed, L, Bourke, L.   +32 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

The GH-IGF-I axis and breast cancer

, 2012
MD (Res)Breast cancer remains one of the most common causes of death amongst women today. Worldwide approximately 1.3 million women are diagnosed as having breast cancer every year.
Laban, Christiana
core  

Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer

, 1997
Background The Collaborative Group on Hormonal Factors in Breast Cancer has brought together and reanalysed about 90% of the worldwide epidemiological evidence on the relation between risk of breast cancer and use of hormone replacement therapy (HRT).
D. Bull, V. Beral, Collaborative Group on Hormonal Factors in Breast Cancer, M. Ferraroni, C. La Vecchia, R. Doll   +5 more
core   +1 more source

Profiling human breast tumor biopsies. gene expression changes associated with ERBB2 status and prognosis, and possible implications for molecular breast cancer classification in the clinic [PDF]

, 2009
Breast cancer is the most common malignancy in women in Western countries, and has proven to be a very heterogeneous disease both on the biological and clinical level.
Urban, Patrick
core   +1 more source

Underserved Patient Populations With Metastatic Breast Cancer: A Review of Progress and Remaining Challenges

The Breast Journal
Breast cancer presents a significant risk to public health and is the primary cause of cancer-related death in women. Awareness of metastatic breast cancer (mBC) continues to increase, and advances have been made; however, challenges remain for many ...
Fatima Cardoso, Rachel Wuerstlein, Tomoyuki Aruga, Renate Haidinger, Matteo Lambertini, Christine Benjamin, Elisenda Llabrés Valentí, Carmen Criscitiello, Matti Aapro, Generosa Grana, Sharon S. Gentry, Eduard Vrdoljak   +11 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Improving the quality of life of people with advanced breast cancer: a global expert review and call-to-action for 2025–2035 (goal 3)

Breast
Progress in the treatment landscape for advanced breast cancer (ABC) has significantly extended the survival of people with the disease. However, longevity alone is insufficient; maintaining and enhancing quality of life (QoL) is vital to ensure that ...
Karen Gelmon, Cynthia Villarreal-Garza, Dawn Aubel, Hope S. Rugo, Julia Maués, Luzia Travado, Matthijs Van Meerveld, Runcie C.W. Chidebe, Bianca Patel, Georgia Attfield, Alexandra Lewis, Fatima Cardoso   +11 more
doaj   +1 more source

Breast cancer biology and ethnic disparities in breast cancer mortality in new zealand: a cohort study.

PLoS ONE, 2015
IntroductionIndigenous Māori women have a 60% higher breast cancer mortality rate compared with European women in New Zealand. We investigated differences in cancer biological characteristics and their impact on breast cancer mortality disparity between ...
Sanjeewa Seneviratne, Ross Lawrenson, Nina Scott, Boa Kim, Rachel Shirley, Ian Campbell   +5 more
doaj   +1 more source