Results 91 to 100 of about 5,496,645 (302)

“My experience has been a terrible one, something I could not run away from”: Zambian women’s experiences of advanced breast cancer

open access: yesInternational Journal of Africa Nursing Sciences, 2015
Breast cancer is the most common cancer in women worldwide and the second most common cancer in women treated at the Cancer Diseases Hospital in Zambia. Unfortunately most women present with advanced disease, too late to be cured.
Johanna E. Maree, J. Mulonda
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. [PDF]

open access: yes, 2012
Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility ...
Dutra-Clarke, Ana   +999 more
core   +4 more sources

Ultrasound findings in the early diagnosis of idiopathic granulomatous mastitis: a large-scale study

open access: yesBMC Medical Imaging
Background Idiopathic granulomatous mastitis (IGM) is a benign but distressing chronic disease. Various etiologies have been proposed for this condition.
Sadaf Alipour   +12 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Maternal pelvic size not predictive of daughter's breast cancer or ovarian cancer in a large Swedish cohort. [PDF]

open access: yes, 2009
Recent studies from Finland reported that maternal pelvic size predicted daughters' breast and ovarian cancer, possibly because maternal pelvic size is a marker for in utero hormone exposure.
Goodman, Anna   +8 more
core   +1 more source

Advances in research and current challenges in the treatment of advanced HER2-low breast cancer

open access: yesFrontiers in Cell and Developmental Biology
Human epidermal growth factor receptor 2 (HER2)-low breast cancer is defined as breast cancer with an immunohistochemistry (IHC) score of 1+ or 2+ and in situ hybridisation (ISH)-negative.
Qiang Qin
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones

open access: yes, 2018
Introduction The chemokines Stromal Cell-Derived Factor-1 alpha (SDF-1 alpha/CXCL12) and Monocyte Chemotactic Protein-1 (MCP-1/CCL2) have been implicated in breast cancer progression. We recently reported elevated systemic MCP-1 in breast cancer patients.
Dwyer, Róisín M.   +6 more
core   +1 more source

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 [PDF]

open access: yes, 2011
The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by ...
Donaldson, A.   +999 more
core   +6 more sources

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