Results 91 to 100 of about 410,880 (314)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Ultrasound findings in the early diagnosis of idiopathic granulomatous mastitis: a large-scale study

BMC Medical Imaging
Background Idiopathic granulomatous mastitis (IGM) is a benign but distressing chronic disease. Various etiologies have been proposed for this condition.
Sadaf Alipour, Nasrin Ahmadinezhad, Bita Eslami, Parisa Aziminezhadan, Razieh Heidari, Maryam Sarkardeh, Maryam Tabatabaeian, Fakhrolsadat Madani, Azin Saberi, Ramesh Omranipour, Nahid Nafissi, Fereshteh Abbasvandi, Vahid Samieinezhad   +12 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Prognostic and predictive value of TP53 mutations in node-positive breast cancer patients treated with anthracycline- or anthracycline/taxane-based adjuvant therapy : results from the BIG 02-98 phase III trial [PDF]

, 2012
Introduction: Pre-clinical data suggest p53-dependent anthracycline-induced apoptosis and p53-independent taxane activity. However, dedicated clinical research has not defined a predictive role for TP53 gene mutations. The aim of the current study was to
Emmanuel Quinaux, Prudence A Francis, Lynnette Fernández-Cuesta, Dell'Orto, P, P. Falagan Lotsch, C. Oakman, A. D. Leo, Pierre Hainaut, Hainaut, P, Azambuja, Evandro De, P. A. Francis, Magali Olivier, D. Larsimont, Larsimont, D, E. Quinaux, G. Viale, Dolci, M Stella, M. S. Dolci, Martine Piccart-Gebhart, Francis, Prudence A, Oakman, C, Dell'orto, Patrizia, Viale, Giuseppe, Evandro De Azambuja, Priscila Falagan-Lotsch, Olivier, Magali, Crown, John, L. Fernández Cuesta, Ke-seay Smoth, Hainaut, Pierre, John Crown, Fernández-Cuesta, L, Viale, G, Leo, Angelo, Larsimont, Denis, M. Piccart Gebhart, Fernández-Cuesta, Lynnette, de Azambuja, Evandro, Giuseppe Viale, Falagan-Lotsch, P, Crown, J, Patrizia Dell'Orto, Piccart-Gebhart, Martine, M Stella Dolci, Piccart-Gebhart, M, Buyse, Marc, Quinaux, E, Denis Larsimont, M. Olivier, M. Buyse, Catherine Oakman, Quinaux, Emmanuel, P. Dell'orto, Olivier, M, Oakman, Catherine, Dolci, MS, Leo, Angelo Di, Buyse, M, Smoth, Ke-Seay, P. Hainaut, Smoth, KS, Azambuja, ED, Angelo Di Leo, J. Crown, Leo, AD, Dolci, Stella, E. D. Azambuja, Francis, P, Francis, PA, Falagan-Lotsch, Priscila, Marc Buyse, K. Smoth   +71 more
core   +1 more source

Advances in research and current challenges in the treatment of advanced HER2-low breast cancer

Frontiers in Cell and Developmental Biology
Human epidermal growth factor receptor 2 (HER2)-low breast cancer is defined as breast cancer with an immunohistochemistry (IHC) score of 1+ or 2+ and in situ hybridisation (ISH)-negative.
Qiang Qin
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A comparison of cognitive function, sleep and activity levels in disease-free breast cancer patients with or without cancer-related fatigue syndrome.

, 2013
Chronic fatigue is a feature in a subset of women successfully treated for breast cancer but is not well characterised. This study examines differences in objective cognitive function, activity levels and sleep in disease-free women who do and do not ...
Minton, O, Stone, PC
core   +1 more source

Breast cancer knowledge, beliefs, attitudes and screening efforts by micro-community of advanced breast cancer patients in Ghana

International Journal of Africa Nursing Sciences, 2019
The burden of breast cancer is greater in Ghana because most women present with advanced disease with poor prognostic outcomes. A person’s health beliefs, experiences, exposures, and disease representation have been noted to influence his/her health ...
Adwoa Bemah Bonsu, Busisiwe Purity Ncama, Kwadwo Osei Bonsu   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Comparison of Digital and Screen-Film Mammography for Breast-Cancer Screening: A Systematic Review and Meta-Analysis [PDF]

, 2019
Purpose: Digital mammography (DM) has replaced screen-film mammography (SFM). However, findings of comparisons between the performance indicators of DM and SFM for breast-cancer screening have been inconsistent.
김민정
core   +1 more source