Results 231 to 240 of about 5,496,645 (302)

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer - results from the phase II DETECT IVb trial. [PDF]

Breast Cancer Res Treat
Schochter F, Friedl TWP, Schäffler H, Meier-Stiegen F, Pfister KN, Riethdorf S, Wiesmüller L, Neubauer H, Müller L, Wimberger P, Fasching PA, Lorenz R, Hempel T, Heublein S, Hartkopf A, Pantel K, Rack B, Müller V, Fehm T, Janni W, Cieslik JP.   +20 more
europepmc   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

CDK4/6 inhibitor combined with endocrine therapy: a real-world evaluation of efficacy and safety in HR+/HER2- advanced breast cancer. [PDF]

World J Surg Oncol
Wang R, Wang Y, Zeng Y, Tu X, Lu D, Zhang P.   +5 more
europepmc   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Circulating DNA tumor fraction as a biomarker for advanced breast cancer. [PDF]

Front Oncol
Cybulla E, Stover DG.
europepmc   +1 more source

Helical Tomotherapy in Local Advanced Breast Cancer Following Mastectomy: Long-term Results and Late Toxicity Analysis. [PDF]

In Vivo
Raether LP, Schempp M, Klepper R, Hauswald H, Hoefel S, Huber PE, Debus J, Zwicker F.   +7 more
europepmc   +1 more source

Dynamic circulating tumor DNA profiling of ESR1 mutations in HR+/HER2- advanced breast cancer: from prognostic biomarker to clinical decision-making - a comprehensive review. [PDF]

Front Oncol
Ren S, Li P, Zhu D, Zhao L, Zhang X.
europepmc   +1 more source

The timing of surgery for elderly patients with locally advanced breast cancer. [PDF]

Transl Cancer Res
Liu J, Mao H, Wu Z, Zhuang W, Weng Y, Lin J, Guo J, Hua Z.   +7 more
europepmc   +1 more source

Results of the feasibility study of clinical trials of the new cancer treatment technology Karanahan for patients with advanced breast cancer. [PDF]

Transl Cancer Res
Proskurina AS, Markina VA, Ruzanova VS, Ritter GS, Dolgova EV, Kirikovich SS, Levites EV, Efremov YR, Vereschagin EI, Leplina OY, Ostanin AA, Chernykh ER, Kolchanov NA, Sidorov SV, Bogachev SS.   +14 more
europepmc   +1 more source