Results 11 to 20 of about 2,225,628 (361)

Comparative Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Advanced Cancer: A Systematic Review and Meta-Analysis

Frontiers in Pharmacology, 2020
BackgroundCombination therapy with immune checkpoint inhibitors (ICIs) has been applied in the clinic to achieve synergistic effects and to improve clinical efficacy.
Yi Yang, Yi Yang, Gang Jin, Yao Pang, Yijie Huang, Wenhao Wang, Hongyi Zhang, Guangxin Tuo, Guangxin Tuo, Peng Wu, Peng Wu, Zequan Wang, Zijiang Zhu   +12 more
doaj   +1 more source

Perceived Dignity of Advanced Cancer Patients and Its Relationship to Sociodemographic, Clinical, and Psychological Factors

Frontiers in Psychology, 2022
ObjectiveLoss of dignity is one of the main reasons for wishing for an early death in patients with incurable diseases such as cancer and is strongly associated with psychological distress and loss of quality of life.
Berta Obispo, Patricia Cruz-Castellanos, Raquel Hernandez, Mireia Gil-Raga, Manuel González-Moya, Jacobo Rogado, Helena López-Ceballos, Miguel García-Carrasco, Paula Jiménez-Fonseca, Caterina Calderon   +9 more
doaj   +1 more source

Palliative Gastrointestinal Surgery in Patients With Advanced Peritoneal Carcinomatosis: Clinical Experience and Development of a Predictive Model for Surgical Outcomes

Frontiers in Oncology, 2022
BackgroundPalliative gastrointestinal (GI) surgery potentially relieves distressing symptoms arising from intestinal obstruction (IO) in patients with advanced peritoneal carcinomatosis (PC).
Jolene Si Min Wong, Jolene Si Min Wong, Jolene Si Min Wong, Jolene Si Min Wong, Sze Min Lek, Daniel Yan Zheng Lim, Claramae Shulyn Chia, Claramae Shulyn Chia, Claramae Shulyn Chia, Claramae Shulyn Chia, Grace Hwei Ching Tan, Grace Hwei Ching Tan, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Melissa Ching Ching Teo, Melissa Ching Ching Teo, Melissa Ching Ching Teo, Melissa Ching Ching Teo   +21 more
doaj   +1 more source

Diagnostic models for impending death in terminally ill cancer patients: A multicenter cohort study

Cancer Medicine, 2021
Background Accurately predicting impending death is essential for clinicians to clarify goals of care. We aimed to develop diagnostic models to predict death ≤3 days in cancer patients.
Masanori Mori, Takuhiro Yamaguchi, Isseki Maeda, Yutaka Hatano, Takashi Yamaguchi, Kengo Imai, Ayako Kikuchi, Yosuke Matsuda, Kozue Suzuki, Satoru Tsuneto, David Hui, Tatsuya Morita, EASED collaborators   +12 more
doaj   +1 more source

Advancements in Cancer Immunotherapies

Vaccines, 2022
Recent work has suggested involvement of the immune system in biological therapies specifically targeting tumor microenvironment. Substantial advancement in the treatment of malignant tumors utilizing immune cells, most importantly T cells that play a key role in cell-mediated immunity, have led to success in clinical trials.
Ruchi Roy, Sunil Singh, Sweta Misra
openaire   +3 more sources

The next steps in improving the outcomes of advanced ovarian cancer [PDF]

, 2015
Worldwide ovarian cancer affects over 200,000 women per year. Overall survival rates are poor due to two predominate reasons. First, the majority of patients present with advanced disease creating significant difficulty with effecting disease eradication.
Blagden, S, Fotopoulou, C, Gabra, H, Openshaw, MR   +3 more
core   +1 more source

“3‐Day Surprise Question” to predict prognosis of advanced cancer patients with impending death: Multicenter prospective observational study

Cancer Medicine, 2021
Background The study aimed to clarify the efficacy of the “3‐Day Surprise Question (3DSQ)” in predicting the prognosis for advanced cancer patients with impending death.
Tomoo Ikari, Yusuke Hiratsuka, Takuhiro Yamaguchi, Isseki Maeda, Masanori Mori, Yu Uneno, Tomohiko Taniyama, Yosuke Matsuda, Kiyofumi Oya, Keita Tagami, Akira Inoue   +10 more
doaj   +1 more source

Clinical relevance of soluble c-erbB-2 for patients with metastatic breast cancer predicting the response to second-line hormone or chemotherapy [PDF]

, 2002
Concentrations of soluble c-erbB-2 were determined in the sera of 64 patients with distant metastasis from advanced breast cancer receiving second-line hormone or chemotherapy in comparison to 35 breast cancer patients without detectable recurrent ...
Classen, S., Eiermann, W., Kopp, R., Possinger, K., Weidenhagen, R., Wilmanns, W.   +5 more
core   +1 more source

Mechanical suppression of osteolytic bone metastases in advanced breast cancer patients: A randomised controlled study protocol evaluating safety, feasibility and preliminary efficacy of exercise as a targeted medicine [PDF]

, 2018
Background: Skeletal metastases present a major challenge for clinicians, representing an advanced and typically incurable stage of cancer. Bone is also the most common location for metastatic breast carcinoma, with skeletal lesions identified in over 80%
Chee, Raphael, Clay, Tim, Feeney, Kynan T, Galvao, Daniel A, Hart, Nicolas H, Martin, Hilary, Newton, Robert U, Redfern, Andrew D, Saunders, Christobel, Spry, Nigel A, Taaffe, Dennis R, Tsoi, Daphne   +11 more
core   +7 more sources

Current perspective - Trastuzumab [PDF]

, 2009
This article will review the available clinical data on the efficacy of trastuzumab in the treatment of both early advanced breast ...
Cameron, D.A., Hall, P.S.
core   +1 more source