Results 51 to 60 of about 288,723 (312)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Chinese expert consensus on clinical practice of locally advanced gastric cancer invading adjacent organs (2024 edition) [PDF]
Zhongguo aizheng zazhiGastric cancer is one of the most common malignant tumors, and over 70% of patients were diagnosed as advanced stage at the first visit in our country. For patients with locally advanced gastric cancer invading adjacent organs, the diagnosis and surgical
Professional Committee on Gastric Cancer of Shanghai Anticancer Association , Professional Committee on Gastrointestinal Cancer of China Association for Promotion of Health Science and Technology
doaj +1 more source
Identification of lncRNA and mRNA regulatory networks associated with gastric cancer progression
Frontiers in Oncology, 2023 Gastric cancer is a tumor type characterized by lymph node metastasis and the invasion of local tissues. There is thus a critical need to clarify the molecular mechanisms governing gastric cancer onset and progression to guide the treatment of this ...
Ke-kang Sun +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Ion Chromatography Based Urine Amino Acid Profiling Applied for Diagnosis of Gastric Cancer
Gastroenterology Research and Practice, 2012 Aim. Amino acid metabolism in cancer patients differs from that in healthy people. In the study, we performed urine-free amino acid profile of gastric cancer at different stages and health subjects to explore potential biomarkers for diagnosing or ...
Jing Fan +3 more
doaj +1 more source
Application and challenge of immunotherapy in perioperative therapy of gastric cancer [PDF]
Zhongguo aizheng zazhiGastric cancer is one of the common malignant tumors of digestive system in our country. The proportion of patients in advanced and late stage is large, and the choice of perioperative treatment program is always difficult in clinic.
XUE Chi, GAO Peng, ZHU Zhi, WANG Zhenning
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundScreening endoscopy is considered to be the most accurate tool for early detection of gastric cancer, but it is both invasive and costly. It is therefore essential to develop cost-effective and non-invasive diagnostic tools for gastric cancer ...
Yoon Ju Jung +5 more
doaj +1 more source
Magnetic Resonance Imaging with Diffuse Weighted Imaging and Computed Tomography with Intravenous Contrast in Staging of Disseminated Ovarian, Stomach, Colorectal Cancer [PDF]
, 2019 The aim of the research. Development and implementation of new methods for pre-operative staging of advanced ovarian, gastric and colorectal cancer to improve patient selection for cytoreductive surgery and increase its radicality.Materials and methods ...
Chetverikov, M. (Mykhailo) +4 more
core
Palliative stenting for oesophagogastric cancer: tumour and host factors and prognosis [PDF]
, 2018 Objectives: Palliative self-expandable metallic stent (SEMS) insertion is common in patients not suitable for resection of oesophagogastric (OG) cancer. Factors which may determine survival, however, are not clear.
Glen, Paul +3 more
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source