Results 91 to 100 of about 41,734 (249)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Advanced Hemodynamic Monitoring: Pros, Cons, and the Future

This chapter offers a comprehensive comparison of advanced hemodynamic monitoring methods by evaluating the well-established pulmonary artery catheter (PAC) alongside emerging semi-invasive and minimally invasive techniques. It outlines the evolution and clinical utility of PACs, emphasizing their role in managing critically ill patients with ...
Malek Abusannuga, Zakria Attique, Sara Abdulla, Hassam Zulfiqar, Moza Almohannadi, Fathimath Shajahan   +5 more
openaire   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Case Report: Anesthetic management of two dogs with third-degree atrioventricular block undergoing elective non-cardiac surgery under temporary transvenous pacing

Frontiers in Veterinary Science
Anesthesizing patients with severe bradycardia caused by conduction disturbances poses a substantial perioperative risk and requires immediate access to pacing and advanced hemodynamic support. Two dogs were presented with a third-degree atrioventricular
Bernadette Vogel, Nicolai Hildebrandt, Kai Kneissl, Franz Söbbeler, Matthias Schneider   +4 more
doaj   +1 more source

Advancements in Bio‐Integrated Flexible Electronics for Hemodynamic Monitoring in Cardiovascular Healthcare

Advanced Science
Abstract Cardiovascular diseases (CVDs) remain the leading cause of global mortality, highlighting the urgent need for effective monitoring and prevention strategies. The rapid advancement of flexible sensing technology and the development of conformal sensors have attracted significant attention due to their potential for continuous,
Ke Huang, Zhiqiang Ma, Bee Luan Khoo
openaire   +3 more sources

Peri-intubation Cardiovascular Collapse During Emergency Airway Management

Pulmonary Therapy
Emergency airway management is a lifesaving procedure but can be associated with significant risks, including hypoxia, hypotension, cardiac arrest, and death.
Samuel I. Garcia, Nathan J. Smischney, Benjamin J. Sandefur, Jacopo D’Andria Ursoleo, Diana J. Kelm, Patrick M. Wieruszewski   +5 more
doaj   +1 more source

Radial capacity and hemodynamics evaluation in vitro and implantable feasibility validation in vivo of thinner bioresorbable polymer vascular stents

BMEMat, EarlyView.
A series of in vitro experiments, numerical simulations and in vivo experiments were conducted to jointly evaluate the effects of different thicknesses of bioabsorbable polymer vascular stents on their radial capacity, hemodynamics and in vivo outcomes.
Chong Chen, Tao Li, Zhongyou Li, Jingyuan Zhou, Zhuo Zhang, Yan Xiong, Rifang Luo, Yu Chen, Yunbing Wang, Ping Fu   +9 more
wiley   +1 more source

Advanced Hemodynamic Monitoring in Polytraumatized Patients: A Comprehensive Review

Journal of Medical Science and Evidences
INTRODUCTION Advanced hemodynamic monitoring plays a crucial role in optimizing the perioperative management of polytraumatized patients, allowing for real-time assessment of cardiovascular status and guiding goal-directed therapy. Traditional monitoring methods, while widely used, have significant limitations that may hinder their effectiveness in ...
Henrique Bosso, null Teófilo Augusto Araújo Tiradentes, null Elias Salomão Maluf, null Mateus Fonseca Freires, null Thiago Luengo Tavares, null Gustavo Ebihara Ziemba Vera, null Gabriel Victor Rebouças Freire, null Rafaela Monteiro de Miranda, null Júlia Spadafora do Amaral   +8 more
openaire   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source