Results 81 to 90 of about 7,571,371 (245)
TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains
Advanced Science, EarlyView.Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang +14 more
wiley +1 more source
Advanced maternal age pregnancy and psychological well-being. [PDF]
, 2023 Pregnancy in advannced maternal age is a complex phenomenon influenced by social, psychological and physical factors. Advanced maternal age, defined as pregnancy at the age, of 35 years and older, is associated with a higher likelihood of medical ...
Pruščikaitė, Neda,
core
Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
Prenatal maternal effects on body condition score, female fertility, and milk yield of dairy cows [PDF]
, 2007 In this study, maternal effects were described as age of dam at first and second calving, first-lactation body condition score (BCS) of the dam during gestation, and milk yield of the dam.
Brotherstone, S. +5 more
core +1 more source
Prion‐Like Protein LENG8‐Mediated Nucleation Drives Stress Granule Assembly
Advanced Science, EarlyView.LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Mingxing Zhang +6 more
wiley +1 more source
Management of Pregnancy in Women of Advanced Maternal Age: Improving Outcomes for Mother and Baby
International Journal of Women's Health, 2021 Itamar Glick,1 Ela Kadish,2 Misgav Rottenstreich1,3 1Department of Obstetrics & Gynecology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel; 2Faculty of Medicine, Hebrew University of Jerusalem ...
Glick I, Kadish E, Rottenstreich M
doaj
Advanced Science, EarlyView.Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang +11 more
wiley +1 more source
Adverse pregnancy outcomes of advanced maternal age pregnant women in Sri Lanka
Journal of the College of Community PhysiciansIntroduction: Pregnant women above 35 years are in advanced maternal age (AMA) and those above 40 years in very advanced maternal age (VAMA). These pregnancies have become common in both low- and high-income countries, including Sri Lanka, showing a ...
Poojani Illangasinghe +2 more
doaj +1 more source
International Journal of Women's Health, 2023 Glick I, Kadish E, Rottenstreich M. Int J Womens Health. 2021;13:751-759. Page 756, Autism Spectrum Disorder section, second paragraph, first sentence, the text “A large meta-analysis, including 16 epidemiological papers with 5687 autism spectrum ...
Glick I, Kadish E, Rottenstreich M
doaj
Obstetrics and Gynecology International, 2020 Introduction. Pregnancy at an advanced maternal age is defined as pregnancy at 35 years or older. Today, women postpone pregnancy due to different socioeconomic and personal reasons.
Bikila Tefera Debelo +2 more
doaj +1 more source