Advanced paternal age alone does not adversely affect pregnancy or live‐birth rates or sperm parameters following intrauterine insemination [PDF]
Reproductive Medicine and Biology, 2018 Purpose This study aimed to evaluate the effect of advanced paternal age on pregnancy outcomes and sperm parameters following intrauterine insemination (IUI).
Takayuki Tatsumi +6 more
doaj +3 more sources
Advanced Paternal Age and Future Generations [PDF]
Frontiers in Endocrinology, 2022 Paternal age at conception has been increasing. In this review, we first present the results from the major mammalian animal models used to establish that increasing paternal age does affect progeny outcome.
Peter T. K. Chan +2 more
doaj +2 more sources
Association of advanced paternal age with lung function at school age [PDF]
Respiratory Research, 2022 Background Epidemiological studies suggest that advanced paternal age impact offspring health, but its impact on respiratory health is unclear. This study aimed to investigate the association of paternal age with lung function and fraction of exhaled ...
Chun-Chun Gau +6 more
doaj +2 more sources
Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health [PDF]
Reproductive Biology and Endocrinology, 2020 Many factors, including postponement of marriage, increased life expectancy, and improved success with assisted reproductive technologies have been contributing to increased paternal age in developed nations.
Iman Halvaei +2 more
doaj +2 more sources
Advanced paternal age directly impacts mouse embryonic placental imprinting. [PDF]
PLoS ONE, 2020 The placental epigenome plays a critical role in regulating mammalian growth and development. Alterations to placental methylation, often observed at imprinted genes, can lead to adverse pregnancy complications such as intrauterine growth restriction and
Michelle M Denomme +5 more
doaj +2 more sources
Identification of hub genes associated with decreased fertility in male mice of advanced paternal age [PDF]
Frontiers in Cell and Developmental BiologyIntroductionAging and delayed parenthood are major social concerns. Men older than 35 years, which is an advanced paternal age, experience reduced sperm quality and fertility.MethodsIn this study, 12-month-old mice served as a model for males of advanced
Yang Gao +8 more
doaj +2 more sources
Gynecology and Obstetrics Clinical Medicine, 2021 Objective: To explore the roles of advanced paternal age (APA) and abnormal paternal weight on embryo quality and pregnancy outcomes for unexplained recurrent pregnancy loss (uRPL) couples who underwent preimplantation genetic testing for aneuploidies ...
Shuo Li +6 more
doaj +3 more sources
Advanced Paternal Age and Sperm DNA Fragmentation: A Systematic Review [PDF]
The World Journal of Men's Health, 2022 Purpose: Male ageing is often associated with defective sperm DNA remodeling mechanisms that result in poorly packaged chromatin and a decreased ability to repair DNA strand breaks.
Daniel C. Gonzalez +5 more
doaj +2 more sources
Advanced Paternal Age and Sperm Proteome Dynamics: A Possible Explanation for Age-Associated Male Fertility Decline [PDF]
CellsMale fertility is strongly influenced by environmental exposures, lifestyle, and advancing age. While advanced paternal age (APA) has been linked with a progressive decline in male fertility, poor reproductive outcomes, and decreased offspring health ...
Joana Santiago +3 more
doaj +2 more sources
Is there an association between advanced paternal age and endophenotype deficit levels in schizophrenia? [PDF]
PLoS ONE, 2014 The children of older fathers have increased risks of developing schizophrenia spectrum disorders, and among those who develop these disorders, those with older fathers present with more severe clinical symptoms.
Debby Tsuang +26 more
doaj +2 more sources