Results 61 to 70 of about 1,981 (241)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Integrity Monitoring for A-PNT Using Barometric Measurements Aided Multi-DMEs

, 2020
International audienceThe Global Navigation Satellite System (GNSS) has been widely used to provide high-precision and high-integrity services for many aeronautical applications.
Milner, Carl, Liang, Xiao, Macabiau, Christophe, Estival, Philippe   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Wide-Sense CDF Overbounding for GNSS Integrity

Navigation
The need for highly reliable positioning in safety-of-life applications has led to the development of global navigation satellite system (GNSS) augmentation systems such as satellite-based augmentation systems and advanced receiver autonomous integrity ...
Odile Maliet, Kin Mimouni, Julie Antic, Sébastien Trilles   +3 more
doaj   +1 more source

Design of an integrity support message for offline advanced RAIM [PDF]

, 2019
The modernization of GPS along with the emergence of new GNSS constellations opens new opportunities to redesign traditional Receiver Autonomous Integrity Monitoring (RAIM) in order to target more demanding navigation requirements.
Perea Diaz, Santiago
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Analysis of BDS ARAIM Integrity Support Data Parameters

Navigation
The realization of the advanced receiver autonomous integrity monitoring (ARAIM) algorithm relies on integrity support data (ISD). To support the use of the BeiDou Navigation Satellite System (BDS) in ARAIM applications, the ISD parameters for BDS are ...
Changjiang Geng Chenghe Fang Zhigang Hu Xiaoli Song Lei Chen Zhipeng Wang, Yilun Cui   +1 more
doaj   +1 more source

Examples of user algorithms implementing ARAIM techniques for integrity performance prediction, procedures development and pre-flight operations

, 2016
Advanced Receiver Autonomous Integrity Monitoring (ARAIM) is a new Aircraft Based Augmentation System (ABAS) technique, firstly presented in the two reports of the GNSS Evolutionary Architecture Study (GEAS). The ARAIM technique offers the opportunity to
S. Paternostro, C. Hill, Atkin, Jason, H.P. Morvan, G. De Maere, T. Moore, Moore, Terry, Morvan, Herve, J. Atkin, Paternostro, S., de Maere, Geert, Hill, Chris   +11 more
core   +1 more source