Results 71 to 80 of about 1,981 (241)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Map-Aided Dead-Reckoning With Lane-Level Maps and Integrity Monitoring

, 2018
International audienceNavigation maps provide critical information for Advanced Driving Assistance Systems and Autonomous Vehicles. When these maps are refined to lane-level, ambiguities may occur during the map-matching process, particularly when ...
Bonnifait, Philippe, Li, Franck, Ibanez-Guzman, Javier   +2 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Parametric Performance Study of Advanced Receiver Autonomous Integrity Monitoring (ARAIM) for Combined GNSS Constellations

, 2011
GPS, Galileo and GLONASS are preparing for the transmission of signals in two protected frequency bands (L1, and L5). The combined use of such signals and the verification of their consistency significantly improve the autonomous integrity of ...
Rippl, Markus, Spletter, Alexandru, Günther, Christoph   +2 more
core  

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Characterizing and Modeling the BDS-3 Time Group Delay Error for ARAIM

Navigation
In the BDS-3 constellation, only the B3I signal is used to compute the broadcast clock offset. However, because advanced receiver autonomous integrity monitoring (ARAIM) uses dual-frequency measurements, the time group delay (TGD) must be considered in ...
Hengwei Zhang, Yiping Jiang, Zhipeng Wang   +2 more
doaj   +1 more source

Global Integrity combining ARAIM and SBAS - Method and Operational Benefit [PDF]

, 2018
Today, Satellite Based Augmentation Systems (SBASs) are in transition to support dual frequency Global Positioning System (GPS) or Galileo. With this evolution comes an architectural change, mitigating some of the time-critical requirements to provision ...
Rippl, Markus, Günther, Christoph, Schlüter, Stefan, Markus Rippl, Perea Diaz, Santiago, Santiago Perea, Stefan Schl�ter, Christoph G�nther   +7 more
core   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source