Results 191 to 200 of about 3,175,008 (304)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Comparative Safety of Advanced Therapies for Crohn Disease.

JAMA Netw Open
Park SK, Ahuja D, Yeh KH, Patel SB, Goodwin SW, Ma C, Singh N, Ananthakrishnan AN, Jairath V, Xu R, Singh S.   +10 more
europepmc   +1 more source

Persistence of advanced therapies in patients with ulcerative colitis: real-world data from the nationwide CREdIT registry. [PDF]

Ther Adv Gastroenterol
Hradsky O, Duricova D, Lukas M, Nedbalová L, Pipek B, Drastich P, Falt P, Vanasek T, Svikova J, Siroky M, Bouchner L, Svoboda P, Bronsky J, Bortlik M.   +13 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Advances in thrombolytic therapy

Journal of British Surgery, 1994
openaire   +2 more sources

Efficacy of Advanced Therapies as Prophylaxis and for Active Disease in Postoperative Crohn's Disease: A Comprehensive Review. [PDF]

J Clin Med
Karimi A, David A, El Ouarzadi O, Battat R.   +3 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The Advanced Therapies model of Lund an integrated approach to accelerate access for many patients. [PDF]

Mol Ther Methods Clin Dev
Helenius G, Jovinge S, Falk A.
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Association of advanced therapies for intermediate- to high-risk pulmonary embolism with improved right ventricular function on outpatient follow-up among survivors. [PDF]

Front Cardiovasc Med
Sheikh H, Singh A, Smith C, Freeman H, Rehman A, Bahk J, Sakul, Dixit K, Yang A, Riasat M, Lookstein R, Argulian E, Steiger DJ.   +12 more
europepmc   +1 more source