Results 41 to 50 of about 7,093,593 (187)

GMP Compliant Production of a Cryopreserved Adipose-Derived Stromal Cell Product for Feasible and Allogeneic Clinical Use

Stem Cells International, 2022
The emerging field of advanced therapy medicinal products (ATMP) holds promise of treating a variety of diseases. Adipose-derived stromal cells (ASCs) are currently being marketed or tested as cell-based therapies in numerous clinical trials.
Mandana Haack-Sørensen, Ellen Mønsted Johansen, Lisbeth Drozd Højgaard, Jens Kastrup, Annette Ekblond   +4 more
doaj   +1 more source

Inactivated herpes simplex virus-1 vaccine formulated in aqueous and alcoholic extracts of propolis boosts cellular and IgG responses [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): In this study, the adjuvant activity of aqueous and alcoholic extracts of propolis was examined on the inactivated herpes simplex virus-1 (HSV-1).Materials and Methods: BALB/C mice were administered with inactivated (HSV-1; the KOS strain ...
Sanaz Mojarab, Pegah Karimi, Delavar Shahbazzadeh, Majid Moghbeli, Kamran Pooshang Bagheri, Arezoo Beig Parikhani, Rada Dehghan, Ehsan Zafari, Amir Moravej, Mohammad Hassan Pouriyayevali, Seyedeh Faranak Mirtalebi, Mahdi Pakjoo, Shaghayegh Yazdani, Meghdad Abdollahpour-alitappeh, Mehdi Mahdavi   +14 more
doaj   +1 more source

Microbiological Aspects of Pharmaceutical Manufacturing of Adipose-Derived Stem Cell-Based Medicinal Products

Cells, 2023
Subcutaneous adipose tissue is an excellent source of mesenchymal stem cells (ADSCs), which can be used in cell therapies as an active substance in advanced therapy medicinal products (ATMPs).
Ilona Szabłowska-Gadomska, Monika Humięcka, Joanna Brzezicka, Anna Chróścicka, Joanna Płaczkowska, Tomasz Ołdak, Malgorzata Lewandowska-Szumiel   +6 more
doaj   +1 more source

Mitigating Deficiencies in Evidence during Regulatory Assessments of Advanced Therapies: A Comparative Study with Other Biologicals

Molecular Therapy: Methods & Clinical Development, 2020
Advanced therapy medicinal products (ATMPs) comprising cell therapy, gene therapy, and tissue-engineered products, offer a multitude of novel therapeutic approaches to a wide range of severe and debilitating diseases.
Magdi Elsallab, Christopher A. Bravery, Andreas Kurtz, Mohamed Abou-El-Enein   +3 more
doaj   +1 more source

A promising combination strategy: oncolytic adenovirus (ΔE1B-55 K/E3) and arsenic trioxide for potent cancer therapy

Scientific Reports
Oncolytic adenovirus has emerged as a promising tool in cancer therapy due to its ability to infect and proliferate preferentially within tumor cells. However, due to its insufficient antitumor activity for effective tumor elimination, various approaches,
Maryam Kadkhodazadeh, Hamed Sabri, Mahdi Pakjoo, Sanam Sadeghi-Mohammadi, Farzaneh Barkhordari, Maryam Bagherian, Ramin Sarrami-Forooshani   +6 more
doaj   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Engineering Intelligent iPSC Biomanufacturing: Integrating Robotic Automation, AI, and Process Control

Advanced Intelligent Systems, EarlyView.
This review highlights recent advances in automated iPSC culture systems integrating robotics, advanced imaging, artificial intelligence, and process control. These technologies improve reproducibility, scalability, and quality in cell expansion, differentiation, and real‐time monitoring, while emerging AI‐enabled and closed‐loop approaches offer new ...
Hyoryong Lee, Roma Desai, Byunggik Kim, Deok‐Ho Kim   +3 more
wiley   +1 more source

From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy

Stem Cell Research & Therapy
Liver cirrhosis, a chronic disease distinguished by extensive scarring in the liver, results in liver dysfunction and fatal complications such as portal hypertension and liver cancer.
Vida Bozorgi, Mahnaz Babaahmadi, Mohammad Salehi, Jamshid Vafaeimanesh, Ensiyeh Hajizadeh-Saffar   +4 more
doaj   +1 more source

Non-hematopoietic essential functions of bone marrow cells: a review of scientific and clinical literature and rationale for treating bone defects

Orthopedic Reviews, 2015
Hematopoiesis as the only essential function of bone marrow cells has been challenged for several decades through basic science (in vitro and in vivo) and clinical data.
David B. Harrell, Eugenio Caradonna, Laura Mazzucco, Rosmarie Gudenus, Berthold Amann, Vaclav Prochazka, Peter V. Giannoudis, Christian Hendrich, Marcus Jäger, Rüdiger Krauspe, Philippe Hernigou   +10 more
doaj   +1 more source

Comprehensive high-resolution genomic profiling and cytogenetics of human chondrocyte cultures by GTG-banding, locus-specific FISH, SKY and SNP array [PDF]

European Cells & Materials, 2018
In the development of cell-based medicinal products, it is crucial to guarantee that the application of such an advanced therapy medicinal product (ATMP) is safe for the patients.
M Wallenborn, O Petters, D Rudolf, H Hantmann, M Richter, P Ahnert, L Rohani, JJ Smink, GC Bulwin, W Krupp, RM Schulz, H Holland   +11 more
doaj   +1 more source