Results 181 to 190 of about 161,336 (304)

Online randomised e-hypnotherapy for chronic pelvic pain study (REST): comparing e-hypnotherapy with relaxation and waitlist to improve pain, cost-effectiveness and biopsychosocial outcomes. [PDF]

BMJ Open
Evans S, Naude C, Coitinho Biurra Y, Bowring J, Knowles S, Brooks T, Skvarc D, Esterman A, Fuller-Tyszkiewicz M, Klas A, Van Niekerk L, McCaffrey N, Stanley K, Druitt M, Andrews J, Vancaillie T, Cheah S, Ciccia D, Blake L, Bassili A, Mikocka-Walus A.   +20 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Tales of rationality: the rational emotive behavioral monomyth as a metaphorical alignment of rational emotive behavior therapy and the Hero's Journey narrative structure. [PDF]

Front Psychol
Turner MJ.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Genre-Specific Gaming Addiction and Flourishing in Adolescents: Cross-Sectional Survey Study.

J Med Internet Res
Luo Y, Chen X, Liu Y, Hong W, Fan M, Thomas D, Mullen SP.   +6 more
europepmc   +1 more source

Impact of mountain biking on adolescent well-being: a scoping review. [PDF]

BMJ Open Sport Exerc Med
Zarbiv G, Perlman S, Slobodin O, Duek O, Ellen ME.   +4 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Bioinspired total syntheses of natural products: a personal adventure. [PDF]

Beilstein J Org Chem
Qin Z, Yang Y, Yan N, Liang X, Zhang Z, Duan Y, Li H, She X.   +7 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Thirty Years of Mentoring by "Bob Chan" of Young Japanese Surgeons to Become Scientists: An Adventure of Love. [PDF]

Ann Gastroenterol Surg
Hoffman RM, Miyake K, Endo I.
europepmc   +1 more source