Results 51 to 60 of about 976,952 (369)

Potential kidney damage associated with the use of remdesivir for COVID-19: analysis of a pharmacovigilance database

open access: yesCadernos de Saúde Pública, 2021
: The U.S. Food and Drug Administration (FDA) has stated that the prescription of remdesivir should be cautious for patients with estimated glomerular filtration rate (eGFR) < 30 and some studies reported risk of adverse renal events.
Nayara Aparecida de Oliveira Silva   +3 more
doaj   +1 more source

Extracting Adverse Drug Events from Clinical Notes [PDF]

open access: yesAmerican Medical Informatics Association (AMIA)-2021 Virtual Informatics Summit, 2021
Adverse drug events (ADEs) are unexpected incidents caused by the administration of a drug or medication. To identify and extract these events, we require information about not just the drug itself but attributes describing the drug (e.g., strength, dosage), the reason why the drug was initially prescribed, and any adverse reaction to the drug.
arxiv  

Statistical Analysis System of Spontaneous Adverse Drug Reaction Reports

open access: yesJournal of Korean Society for Clinical Pharmacology and Therapeutics, 2012
Background: Spontaneous adverse drug reaction (ADR) reporting data has been used for safety of post-market drug surveillance. A system has been required that is able to detect signals associated with drugs by analyzing the collected ADR data. Methods: We developed the web-based automated analysis system (ADR-detector).
Boram Wang   +6 more
openaire   +2 more sources

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

open access: yesMolecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi   +6 more
wiley   +1 more source

BioDEX: Large-Scale Biomedical Adverse Drug Event Extraction for Real-World Pharmacovigilance [PDF]

open access: yesarXiv, 2023
Timely and accurate extraction of Adverse Drug Events (ADE) from biomedical literature is paramount for public safety, but involves slow and costly manual labor. We set out to improve drug safety monitoring (pharmacovigilance, PV) through the use of Natural Language Processing (NLP).
arxiv  

City-wide Analysis of Electronic Health Records Reveals Gender and Age Biases in the Administration of Known Drug-Drug Interactions [PDF]

open access: yesnpj Digit. Med. 2, 74 (2019), 2018
The occurrence of drug-drug-interactions (DDI) from multiple drug dispensations is a serious problem, both for individuals and health-care systems, since patients with complications due to DDI are likely to reenter the system at a costlier level. We present a large-scale longitudinal study (18 months) of the DDI phenomenon at the primary- and secondary-
arxiv   +1 more source

A Prospective Analysis of Adverse Drug Reactions in a South Indian Hospital [PDF]

open access: yes, 2009
Adverse drug reactions are a great cause of concern to the medical profession, the patients and the pharmaceutical industry. However ADR reporting and monitoring is yet to catch up in India.
Adhikari, P, Padmaja, U, Pereira, P
core  

DEVELOPING A CHALLENGES LANDSCAPE RELATING TO DRUG SAFETY, PROVISION, AND DISTRIBUTION IN RESOURCE-LIMITED SETTINGS FOR THE CASE OF HIV/AIDS

open access: yesSouth African Journal of Industrial Engineering, 2018
Since 2010, pharmaceutical organisations have begun to provide drug patents in sub-Saharan Africa through the UN Medicine Patent Pool. This initiative allows any pharmaceutical manufacturer to access these patents and manufacture the drugs, thereby ...
Huysamen, Biance   +2 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

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