Results 51 to 60 of about 143,193 (344)

A Prospective Analysis of Adverse Drug Reactions in a South Indian Hospital [PDF]

, 2009
Adverse drug reactions are a great cause of concern to the medical profession, the patients and the pharmaceutical industry. However ADR reporting and monitoring is yet to catch up in India.
Adhikari, P, Padmaja, U, Pereira, P
core   +3 more sources

Evidence and Extrapolation: Mechanisms for Regulating Off-Label Uses of Drugs and Devices [PDF]

, 2014
A recurring, foundational issue for evidence-based regulation is deciding whether to extend governmental approval from an existing use with sufficient current evidence of safety and efficacy to a novel use for which such evidence is currently lacking ...
Abbott, Ryan, Ayres, Ian
core   +3 more sources

A Multi-Agent System for Reporting Suspected Adverse Drug Reactions

Online Journal of Public Health Informatics, 2014
Adverse drug reactions (ADRs) represent a serious worldwide public health problem. Current post-marketing ADR detection approaches largely rely on spontaneous reports filed by various healthcare professionals such as physicians, pharmacists et.al.. Underreporting is a serious deficiency of these methods - the actually reported adverse events represent ...
Fangyang Shen, John Tran, See-Yan Lau, Yanqing Ji   +3 more
openaire   +3 more sources

Adverse drug reactions reported for systemic antibacterials in Danish children over a decade [PDF]

British Journal of Clinical Pharmacology, 2010
Systemic antibacterials are among the most frequently prescribed drugs in children to treat respiratory tract infections [1, 2]. Empirical studies have shown that Danish children receive more broad-spectrum penicillins compared with children in Italy, Canada and Scandinavia [3–5].
Aagaard, Lise, Hansen, Ebba Holme
openaire   +4 more sources

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Systematic review of the safety of medication use in inpatient, outpatient and primary care settings in the Gulf Cooperation Council countries [PDF]

, 2018
Background Errors in medication use are a patient safety concern globally, with different regions reporting differing error rates, causes of errors and proposed solutions.
Abu Yassin, Abushaiqa, Ackroyd-Stolarz, Al Anany, Al Anazi, Al Hamid, Al Khaja, Al Khaja, Al Khaja, Al Khaja, Al Khaja, Al Odhayani, Al Rahbi, Al Shahaibi, Al-Arifi, Al-Arifi, Al-Dhawailie, Al-Ghamdi, Al-Hussein, Al-Jazairi, Al-Jeraisy, Al-Khani, Al-Olah, Al-Omar, Al-Rashdi, Al-Rowibah, Al-Tajir, Alakhali, Alanazi, Albarrak, Alghamdy, Aljadhey, Aljadhey, Aljadhey, Aljamal, Allan, Almazrou, Alshaikh, Alsulaimi, Altebenaui, American Geriatrics Society Beers Criteria Update Expert Panel, Arabi, Aseeri, ASHP, Bates, Bryony Dean Franklin, Cohen, Dean, Dean, Dean, Dean, Dibbi, Elnour, Ferner, Fick, Flynn, Flynn, Gandhi, Ghaleb, Ghaleb, Hemida, Hepler, Hisham Saad Aljadhey, Hooper, Insley, Irshaid, Jamilah Alsaidan, Jane Portlock, Jha, Jha, Kaushal, Kheir, Khoja, Landis, Lisby, Mahmoud, McLeod, McPhillips, Mendonca, Miller, Mitwally, Morimoto, Morimoto, Nada Atef Shebl, Naranjo, Nebeker, Neville, Rancourt, Rashed, Rashed, Rehmani, Sadat-Ali, Shaughnessy, Sonallah, WHO, World Bank   +95 more
core   +3 more sources

Amyotrophic Lateral Sclerosis as an Adverse Drug Reaction: A Disproportionality Analysis of the Food and Drug Administration Adverse Event Reporting System

Drug Safety, 2022
Amyotrophic lateral sclerosis is a fatal progressive disease with a still unclear multi-factorial etiology. This study focused on the potential relationship between drug exposure and the development of amyotrophic lateral sclerosis by performing a detailed analysis of events reported in the FDA Adverse Event Reporting System database.The FDA Adverse ...
Gaimari A., Fusaroli M., Raschi E., Baldin E., Vignatelli L., Nonino F., De Ponti F., Mandrioli J., Poluzzi E.   +8 more
openaire   +3 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Antiviral treatment for Bell's palsy (idiopathic facial paralysis) [PDF]

, 2009
BACKGROUND: Antiviral agents against herpes simplex virus are widely used in the treatment of idiopathic facial paralysis (Bell's palsy), but their effectiveness is uncertain. Significant morbidity can be associated with severe cases.
Abiko, Adour, Adour KK Swanson, Ahangar, Allen, Allen, Antunes, Aquino, Axelsson, Bateman, Brandenberg, Chen, Diego, Egger, Engström, Goudakos, Hato, Hato, Hernández, House, Hultcranzt, Ibarrondo, Inanli, Katusic, Kawaguchi, May, McCormick, Morgan, Morgenlander, Murakami, Petruzelli, Pietersen, Pietersen, Ramos Macias, Ross, Rowlands, Roy, Salinas, Sipe, Stjernquist-Desatnik, Sugita, Sullivan, Takasu, Theil, Wolf, Yanagihara, Yeo, Zhou   +47 more
core   +3 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source