Results 61 to 70 of about 976,952 (369)

Increasing Adverse Drug Events extraction robustness on social media: case study on negation and speculation [PDF]

arXiv, 2022
In the last decade, an increasing number of users have started reporting Adverse Drug Events (ADE) on social media platforms, blogs, and health forums. Given the large volume of reports, pharmacovigilance has focused on ways to use Natural Language Processing (NLP) techniques to rapidly examine these large collections of text, detecting mentions of ...
arxiv  

A Multi-Agent System for Reporting Suspected Adverse Drug Reactions

Online Journal of Public Health Informatics, 2014
Adverse drug reactions (ADRs) represent a serious worldwide public health problem. Current post-marketing ADR detection approaches largely rely on spontaneous reports filed by various healthcare professionals such as physicians, pharmacists et.al.. Underreporting is a serious deficiency of these methods - the actually reported adverse events represent ...
Fangyang Shen, John Tran, See-Yan Lau, Yanqing Ji   +3 more
openaire   +3 more sources

Interactive exploration of population scale pharmacoepidemiology datasets

, 2020
Population-scale drug prescription data linked with adverse drug reaction (ADR) data supports the fitting of models large enough to detect drug use and ADR patterns that are not detectable using traditional methods on smaller datasets. However, detecting
Abadi M., Furu K., Salathé M., Ventola C. L., Wishart D. S.   +4 more
core   +1 more source

Adverse Events Related to Off-Label Drugs Using Spontaneous Adverse Event Reporting Systems

Therapeutics and Clinical Risk Management, 2021
Nayoung Han,1,2 Jung Mi Oh,1,3 In-Wha Kim1 1Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea; 2College of Pharmacy, Jeju National University, Jejusi, Jeju Special Self-Governing Province, Republic of ...
Han N, Oh JM, Kim IW
doaj  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Adverse drug reactions reported for systemic antibacterials in Danish children over a decade [PDF]

British Journal of Clinical Pharmacology, 2010
Systemic antibacterials are among the most frequently prescribed drugs in children to treat respiratory tract infections [1, 2]. Empirical studies have shown that Danish children receive more broad-spectrum penicillins compared with children in Italy, Canada and Scandinavia [3–5].
Aagaard, Lise, Hansen, Ebba Holme
openaire   +4 more sources

Analysis of Adverse Drug Reactions to First-Line Anti-Tuberculosis Drugs Using the Korea Adverse Event Reporting System

Journal of Korean Medical Science, 2022
Adverse drug reactions (ADRs) to first-line anti-tuberculosis (TB) drugs are common; however, there have been few reports of nationwide epidemiologic studies on ADRs to anti-TB drugs in Korea. This study aimed to investigate the clinical characteristics of various ADRs to first-line anti-TB drugs using a nationwide database of ADRs.We used the Korea ...
Soo Jie Chung, Sun-ju Byeon, Jeong-Hee Choi   +2 more
openaire   +2 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Amyotrophic Lateral Sclerosis as an Adverse Drug Reaction: A Disproportionality Analysis of the Food and Drug Administration Adverse Event Reporting System

Drug Safety, 2022
Amyotrophic lateral sclerosis is a fatal progressive disease with a still unclear multi-factorial etiology. This study focused on the potential relationship between drug exposure and the development of amyotrophic lateral sclerosis by performing a detailed analysis of events reported in the FDA Adverse Event Reporting System database.The FDA Adverse ...
Gaimari A., Fusaroli M., Raschi E., Baldin E., Vignatelli L., Nonino F., De Ponti F., Mandrioli J., Poluzzi E.   +8 more
openaire   +3 more sources

Can the Heinrich ratio be used to predict harm from medication errors? [PDF]

, 2006
The purpose of this study was to establish whether, for medication errors, there exists a fixed Heinrich ratio between the number of incidents which did not result in harm, the number that caused minor harm, and the number that caused serious harm.
Barber, N, Franklin, BD, Gallivan, S, Taxis, K   +3 more
core