Results 81 to 90 of about 976,952 (369)
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
ADRIC: Adverse Drug Reactions In Children - a programme of research using mixed methods [PDF]
, 2014 Aims To comprehensively investigate the incidence, nature and risk factors of adverse drug reactions (ADRs) in a hospital-based population of children, with rigorous assessment of causality, severity and avoidability, and to assess the consequent ...
Arnott, Janine +14 more
core
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Knowledge-augmented Graph Neural Networks with Concept-aware Attention for Adverse Drug Event Detection [PDF]
arXiv, 2023 Adverse drug events (ADEs) are an important aspect of drug safety. Various texts such as biomedical literature, drug reviews, and user posts on social media and medical forums contain a wealth of information about ADEs. Recent studies have applied word embedding and deep learning -based natural language processing to automate ADE detection from text ...
arxiv
A network inference method for large-scale unsupervised identification of novel drug-drug interactions [PDF]
PLoS Comput Biol 9(12): e1003374 (2013), 2014 Characterizing interactions between drugs is important to avoid potentially harmful combinations, to reduce off-target effects of treatments and to fight antibiotic resistant pathogens, among others. Here we present a network inference algorithm to predict uncharacterized drug-drug interactions.
arxiv +1 more source
Patient safety in Europe: medication errors and hospital-acquired infections [PDF]
, 2008 The Report was commissioned by the European Federation of Nurses Associations (EFN) in November 2007 in order to support its policy statements on Patient Safety (June 2004).
Burke, J. +3 more
core +1 more source
Physicians’ Understanding and Practices of Pharmacovigilance Qualitative Experience from a Lower Middle-Income Country [PDF]
, 2020 Developed countries have established pharmacovigilance systems to monitor the safety of medicines. However, in the developing world, drug monitoring and reporting are facing enormous challenges.
Hashmi, Furqan +4 more
core
A pharmacovigilance study in the department of medicine of a university teaching hospital.
Pharmacy Practice, 2007 The aim of the present study was to monitor adverse drug reactions (ADRs) in the Medicine out patient department (OPD) of a University Teaching Hospital.Method: A prospective evaluation of the ADRs reported in the Department of Medicine of our University
Sharma H +5 more
doaj
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
Under-reporting of Adverse Drug Reactions: The Need for an Automated Reporting System
Revue interdisciplinaire des sciences de la santé - Interdisciplinary Journal of Health Sciences, 2013 Although upwards of 32,000 adverse drug reactions are reported to Health Canada annually, this represents only approximately 5% of cases experienced by Canadians every year. This gross display of underreporting not only results in unrepresentative data in regards to adverse drug reactions, but further discredits databases used by healthcare ...
openaire +2 more sources