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Adverse drug reactions [PDF]

BMJ, 2018
Summary Adverse drug reactions are a cause of significant morbidity and mortality to patients and a source of financial burden to the healthcare system. Of the wide spectrum of adverse drug reactions, the most concerning to the anaesthetist remain anaphylaxis and malignant hyperthermia.
Ferner, RE, McGettigan, P
  +9 more sources

Data mining techniques for detecting signals of adverse drug reaction of cardiac therapy drugs based on Jinan adverse event reporting system database: a retrospective study

BMJ Open, 2023
Objective Cardiac therapy drugs are widely used in the treatment of heart disease. However, the concern regarding adverse events (AEs) of cardiac therapy drugs have been rising. This study aimed to analyse cardiac therapy drug-related AEs using the Jinan
Jing Yang, Lei Zheng, Yuyao Guan, Lei Ji, Yingmei Qi, Mingzhu Zhang, Qiuhong Zhang   +6 more
doaj   +1 more source

Adverse drug reactions [PDF]

Clinical Medicine, 2016
Adverse drug reactions (ADRs) remain a challenge in modern healthcare, particularly given the increasing complexity of therapeutics, an ageing population and rising multimorbidity. This article summarises some of the key facts about ADRs and explores aspects relating to their prevention, diagnosis, reporting and management in current clinical practice.
Jamie J, Coleman, Sarah K, Pontefract
openaire   +4 more sources

SARS-CoV-2 vaccine excipients polyethylene glycol and trometamol do not induce mast cell degranulation, in an in vitro model for non-IgE-mediated hypersensitivity

Frontiers in Allergy, 2022
The development of vaccines against SARS-CoV2 brought about several challenges, including the management of hypersensitivity reactions to these formulations.
Paola Leonor Quan, Laia Ollé, Laia Ollé, Marina Sabaté-Brescó, Marina Sabaté-Brescó, Marina Sabaté-Brescó, Yanru Guo, Yanru Guo, Rosa Muñoz-Cano, Rosa Muñoz-Cano, Rosa Muñoz-Cano, Annette Wagner, Gabriel Gastaminza, Gabriel Gastaminza, Gabriel Gastaminza, Margarita Martín, Margarita Martín, Margarita Martín   +17 more
doaj   +1 more source

Differences in Linear Epitopes of Ara h 9 Recognition in Peanut Allergic and Tolerant, Peach Allergic Patients

Frontiers in Allergy, 2022
BackgroundPeanut-allergic patients from the Mediterranean region are predominantly sensitized to the lipid transfer protein (LTP) Ara h 9, and the peach LTP Pru p 3 seems to be the primary sensitizer. However, LTP sensitization in peanut allergy is not a
L. Sánchez-Ruano, C. Fernández-Lozano, M. Ferrer, M. Ferrer, F. Gómez, F. Gómez, B. de la Hoz, B. de la Hoz, J. Martínez-Botas, J. Martínez-Botas, M. J. Goikoetxea, M. J. Goikoetxea   +11 more
doaj   +1 more source

Intradermal Testing With COVID-19 mRNA Vaccines Predicts Tolerance

Frontiers in Allergy, 2022
BackgroundThe newly developed mRNA-based COVID-19 vaccines can provoke anaphylaxis, possibly induced by polyethylene glycol (PEG) contained in the vaccine.
Florian Stehlin, Rima Mahdi-Aljedani, Loris Canton, Véronique Monzambani-Banderet, Alix Miauton, Cedric Girard, Kevin Kammermann, Sylvain Meylan, Camillo Ribi, Thomas Harr, Daniel Yerly, Yannick D. Muller   +11 more
doaj   +1 more source

MRGPRX2 and Adverse Drug Reactions

Frontiers in Immunology, 2021
Many adverse reactions to therapeutic drugs appear to be allergic in nature, and are thought to be triggered by patient-specific Immunoglobulin E (IgE) antibodies that recognize the drug molecules and form complexes with them that activate mast cells ...
Benjamin D. McNeil
doaj   +1 more source

Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline

mAbs, 2020
Monoclonal antibody (mAb) therapy has been previously exploited for viral infections, such as respiratory syncytial virus pneumonia and Ebolavirus disease.
Marco Tuccori, Sara Ferraro, Irma Convertino, Emiliano Cappello, Giulia Valdiserra, Corrado Blandizzi, Fabrizio Maggi, Daniele Focosi   +7 more
doaj   +1 more source

Activity of Moxifloxacin Against Biofilms Formed by Clinical Isolates of Staphylococcus aureus Differing by Their Resistant or Persister Character to Fluoroquinolones

Frontiers in Microbiology, 2021
Staphylococcus aureus biofilms are poorly responsive to antibiotics. Underlying reasons include a matrix effect preventing drug access to embedded bacteria, or the presence of dormant bacteria with reduced growth rate.
Tiep K. Nguyen, Tiep K. Nguyen, Frédéric Peyrusson, Wafi Siala, Nhung H. Pham, Hoang A. Nguyen, Paul M. Tulkens, Françoise Van Bambeke   +7 more
doaj   +1 more source

Safety Profile of Biological Drugs in Clinical Practice: A Retrospective Pharmacovigilance Study

Iraqi Journal of Pharmaceutical Sciences, 2022
Biological drugs have an active substance that is made by a living organism or derived from a living organism. They are one of the important therapy options used in a wide range of diseases especially life-threatening diseases.
Elaaf Fadhil Hassan, Dheyaa j Kadhim, Manal m Younus   +2 more
doaj   +1 more source