Results 41 to 50 of about 585,279 (298)

Ranking Adverse Drug Reactions With Crowdsourcing

Journal of Medical Internet Research, 2015
BackgroundThere is no publicly available resource that provides the relative severity of adverse drug reactions (ADRs). Such a resource would be useful for several applications, including assessment of the risks and benefits of drugs and improvement of ...
Gottlieb, Assaf, Hoehndorf, Robert, Dumontier, Michel, Altman, Russ B   +3 more
doaj   +1 more source

A prospective observational study of ophthalmic adverse drug reactions in a tertiary care hospital

National Journal of Physiology, Pharmacy and Pharmacology, 2021
Background: According to an epidemiological study, 1.7–25.1% of eye disease was drug induced, but the evidence of adverse drug reactions (ADRs) in ophthalmology is found to be scarce, as it is difficult in correlation between symptoms and ocular signs ...
Vasundara Krishnaiah, R S Umadevi, Leeyasid Shaik   +2 more
doaj   +1 more source

Adverse drug reactions in older people : detection and prevention [PDF]

, 2012
Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality.
Onder, Graziano, Petrovic, Mirko, van der Cammen, Tischa   +2 more
core   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Spontaneous notification of adverse drug reactions

Revista Cubana de Medicina Militar, 2021
Introduction: The proper use of medications eliminates or controls numerous diseases, contributes to the well-being of the population and increases life expectancy; but it can also generate adverse reactions, which must be reported to identify new risks ...
Laura Barrero Viera, Luis Alberto Bestard Pavón   +1 more
doaj  

HLA‐associated adverse drug reactions ‐ scoping review

Clinical and Translational Science, 2021
Alleles of the human leukocyte antigen (HLA) system have been associated with the occurrence of idiosyncratic adverse drug reactions (ADRs). Accordingly, it is assumed that pre‐emptive testing for the presence of certain HLA alleles (HLA‐typing) could ...
Chiara Jeiziner, Ursina Wernli, Katja Suter, Kurt E. Hersberger, Henriette E. Meyer zu Schwabedissen   +4 more
doaj   +1 more source

Pharmacovigilance of Antiretroviral Drugs at B.P. Koirala Institute of Health sciences

Journal of Nepal Health Research Council, 2021
Background: Antiretroviral drugs are lifeline for patients living with HIV. Adverse drug reactions can compromise the compliance to antiretroviral therapy.
Deependra Prasad Sarraf, Gajendra Prasad Rauniar, Roshan Chhetri, Shyam Prasad Kafle, Suchana Marahatta, Basudha Khanal, Sanjib Kumar Sharma, Vivek Kattel   +7 more
doaj   +1 more source

Utilizing Multi-level Classification Techniques to Predict Adverse Drug Effects and Reactions [PDF]

, 2019
Multi-class classification models are used to predict categorical response variables with more than two possible outcomes. A collection of multi-class classification techniques such as Multinomial Logistic Regression, Na\ {i}ve Bayes, and Support Vector ...
Puhl, Victoria
core   +1 more source

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

Mining and evaluation of security alert signals of neuroprotective agents based on the Jinan adverse event reporting system database: a retrospective study

Frontiers in Pharmacology
BackgroundPharmacologic agents with proposed neuroprotective properties are increasingly investigated; however, limited regulation and heterogeneous evidence raise concerns about their safety profiles. To establish a foundation for its safe clinical use,
Yu-yao Guan, Jing Yang, Ying-mei Qi, Chao Song, Lei Zheng   +4 more
doaj   +1 more source