Results 61 to 70 of about 585,279 (298)

Adverse drug reactions to tocolytic treatment for preterm labour: Prospective cohort study [PDF]

, 2009
Objective To evaluate the incidence of serious maternal complications after the use of various tocolytic drugs for the treatment of preterm labour in routine clinical situations. Design Prospective cohort study.
Duvekot, J.J. (Hans), Erwich, J.J.H.M., Famschobben, F., Geijn, H.P. (Herman) van, Gyselaers, W.J. (Wilfried), Hanssens, M. (Myriam), Harmark, L. (Linda), Heus, R. (Roel) de, Holsbeke, C.D. (Caroline) van, Mol, B.W.J. (Ben), Visser, G.H. (Gerhard Henk), Wolf, H. (Hans Uwe)   +11 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

KNOWLEDGE, ATTITUDE AND PRACTICE AMONG HEALTHCARE PROFESSIONALS TOWARDS ADR REPORTING IN ABBOTTABAD PAKISTAN

International Journal of Pharmacy & Integrated Health Sciences, 2021
Background: Healthcare professionals can play an important role in reporting adverse drug reactions as it is a global health problem and required to be addressed.
doaj   +1 more source

Viewpoint on handling anti-TNF failure in psoriasis [PDF]

, 2013
An association among the occurrence of antidrug antibodies (ADAs), diminished trough serum drug levels (TSDLs) and non-response or loss of response has been described for several tumor necrosis factor alpha (TNF) blocking agents in a variety of diseases,
BRACKE, STEFANIE, Lambert, Jo
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Adverse drug reactions

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 1999
It has been established that drugs can’t be useful without causing side effects at the same time. There are many different variables contributing the development of these adverse effects, such as pharmaceutical (Change in the main effective substance of ...
AA Moghadam Nia
doaj  

Effectiveness of Seasonal Malaria Chemoprevention in children under 10 years of age in Senegal: a stepped-wedge cluster-randomized trial [PDF]

, 2016
This study was done to determine the effectiveness of Seasonal Malaria Chemoprevention in Senegalese children up to 10 years of age using a stepped-wedge design.
Milligan, Paul
core   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Multi-Task Pharmacovigilance Mining from Social Media Posts

, 2018
Social media has grown to be a crucial information source for pharmacovigilance studies where an increasing number of people post adverse reactions to medical drugs that are previously unreported.
Chowdhury, Shaika, Yu, Philip S., Zhang, Chenwei   +2 more
core   +1 more source

Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records [PDF]

, 2017
Unknown adverse reactions to drugs available on the market present a significant health risk and limit accurate judgement of the cost/benefit trade-off for medications.
Bean, DM, Broadbent, M, Dobson, RJB, Dzahini, O, Stewart, R, Wu, H   +5 more
core   +1 more source