Results 71 to 80 of about 4,166,301 (304)

Assessment of the expectancy, seriousness and severity of adverse drug reactions reported for chronic obstructive pulmonary disease therapy

SAGE Open Medicine, 2017
Introduction: Adverse drug reactions can cause increased morbidity and mortality, and therefore information needs to be studied systematically. Little is known about the adverse drug reactions for chronic obstructive pulmonary disease therapy.
Guenka Petrova, Assena Stoimenova, Maria Dimitrova, Maria Kamusheva, Daniela Petrova, Ognian Georgiev   +5 more
doaj   +1 more source

Incidence of adverse drug reactions.^*

, 2016
Incidence of adverse drug reactions.*
Monique Wasunna (157135), Fabiana Alves (217602), Neal Alexander (18417), Thomas P. C. Dorlo (321337), Sally Ellis (157129), Eltahir Awad Gasim Khalil (3119940), Susan Wells (3119952), Rashid Juma (463480), Anke E. Kip (3119949), Joseph Olobo (156982), Simon Njenga (3119955), Gerard J. Schoone (244545), Manica Balasegaram (156987), Nathalie Strub Wourgaft (3119943), George Kirigi (157066), Robert Kimutai (157106), Raymond Omollo (156992), Asrat Hailu (59005), Mohammed Hassan Sharaf Ali (3119958), Mohammed Yasein Elamin (3119946), Brima Musa (157009), Ahmed Musa (156973), Tansy Edwards (122527)   +22 more
core   +1 more source

Evaluation of patient reporting of adverse drug reactions to the UK ‘Yellow Card Scheme’: literature review, descriptive and qualitative analyses, and questionnaire surveys [PDF]

, 2011
Background: The monitoring of adverse drug reactions (ADRs) through pharmacovigilance is vital to patient safety. Spontaneous reporting of ADRs is one method of pharmacovigilance, and in the UK this is undertaken through the Yellow Card Scheme (YCS ...
DJ McLernon, Murphy, E., Fortnum, H, Watson, M C, McLernon, D.J., Hazell, L, Gifford, A., MC Watson, Fortnum, H., Watson, M.C., Bond, C. M., Lee, A.J., Avery, A J, Bond, Christine, Hannaford, P.C., Krska, Janet, Watson, M. C., Avery, Anthony, J Krska, Krska, J, Mclernon, David J., Hannaford, P C, Shakir, S., Lee, A J, Lee, A. J., Gifford, A, Murphy, E, CM Bond, E Murphy, L Hazell, Hazell, L., Gifford, Alison, Watson, Margaret C., A Gifford, H Fortnum, AJ Avery, Bond, C.M., C Anderson, Anderson, C., Anderson, C, S Shakir, McLernon, D. J., McLernon, D J, Anderson, Claire, Bond, C M, Fortnum, Heather, Shakir, S, Avery, A. J., PC Hannaford, Murphy, Elizabeth, Hannaford, P. C., Hannaford, Philip C., AJ Lee, Krska, J., Watson, M. C.; id_orcid   +54 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Association between adverse drug reactions and prescribed drug use.

, 2019
Association between adverse drug reactions and prescribed drug use.
Muhammad Junaid Farrukh (7490333), Syeda Sidra (7490327), Muhammad Haseeb Tariq (7490330), Muhammad Mohsin (1335447)   +3 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Primary motivations for publishing adverse drug reactions.

, 2019
Primary motivations for publishing adverse drug reactions.
Oliver Sartor (4102138), Kevin B. Knopf (7109324), Ashley Godwin (7109300), Y. Tony Yang (3170937), Henry C. Ausdenmoore (7109306), Terence Young (7109321), William J. Hrushesky (7109312), Paul R. Yarnold (7109318), Bartlett J. Witherspoon (7109297), Brian Chen (149932), Charles L. Bennett (329817), Matthew A. Taylor (7109294), Jayanth Vemula (7109303), Benjamin Schooley (7109291), James O. Armitage (7109309), John Restaino (7109315), Henrik S. Thomsen (494716)   +16 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Drug Information Centre service analysis V. - adverse drug reactions

, 2022
Drug Information Centre service analysis V. - Adverse drug reactions Author: Adam Badura Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr.
Badura, Adam
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