Results 61 to 70 of about 1,968,981 (315)

Systematic review and meta- analysis of selected health effects of long-term exposure to traffic-related air pollution

, 2022
This comprehensive scientific review, available for downloading below, examines the evidence for associations between several adverse health effects and traffic-related air pollution (TRAP). The review, the largest of its type to date, was conducted by a
panel on the health effects of long-term exposure to traffic-rel, H. E. I.
core  

Enhancing Communication about Paediatric Medicines: Lessons from a Qualitative Study of Parents' Experiences of Their Child's Suspected Adverse Drug Reaction [PDF]

, 2012
Background: There is little research on parents' experiences of suspected adverse drug reactions in their children and hence little evidence to guide clinicians when communicating with families about problems associated with medicines.
Smyth, RL, Young, B., Hesselgreaves, H, Munir Pirmohamed (40546), Janine Arnott (128747), Turner, M.A., Anthony J Nunn, Rosalind L. Smyth (80205), Mark A. Turner (114089), Hesselgreaves Hannah, Nunn, Anthony J., Nunn Anthony J., Nunn, Anthony J, Turner, Mark A, Matthew Peak (114087), Hesselgreaves, H., Pirmohamed, Munir, Nunn, AJ, Pirmohamed, M, Peak, M, Munir Pirmohamed, Smyth Rosalind L., Janine Arnott, Arnott Janine, Pirmohamed Munir, Nunn, A.J., Hannah Hesselgreaves (128748), Peak, M., Bridget Young (128749), Hannah Hesselgreaves, Bridget Young, Anthony J. Nunn (114088), Young, Bridget, Matthew Peak, Arnott, J, Turner Mark A., Turner, MA, Young, B, Rosalind L Smyth, Pirmohamed, M., Smyth, Rosalind L., Hesselgreaves, Hannah, Mark A Turner, Smyth, Rosalind L, Arnott, Janine, Young Bridget, Peak Matthew, Arnott, J., Smyth, R.L., Peak, Matthew, Turner, Mark A.   +50 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Reversible cycloplegia caused by duloxetine: a case report

Psychiatry and Clinical Psychopharmacology, 2017
A Duloxetine is a balanced and potent dual reuptake inhibitor of serotonin and norepinephrine (SNRI) that has previously been shown to be effective in the treatment of major depressive disorder (MDD), generalized anxiety disorder, and diabetic peripheral
Rabia Nazik Yüksel, Vahap Ozan Kotan, Erol Göka   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Clinical safety issues of measles, mumps and rubella vaccines

Bulletin of the World Health Organization, 2000
The clinical safety of measles and measles-mumps-rubella vaccines has been questioned in recent reports that propose a possible link between measles virus or measles vaccines and the occurrence of juvenile Crohn disease and autism.
M.A. Afzal, P.D. Minor, G.C. Schild
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Skin reactions probably attributed to the use of phenytoin and vancomycin [PDF]

Einstein (São Paulo), 2008
Cutaneous reactions are the most common adverse events attributed to medications. Stevens-Johnson syndrome or erythema multiforme is a severe and acute reaction determined by medications, especially aspirin, phenytoin, and vancomycin.
Carla Tozato, Márcia de Alcantara, Jacyr Pasternak   +2 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source