Results 81 to 90 of about 3,542,749 (309)
A Rare Case of Inflammatory Myositis Post-intramuscular Injections of Onabotulinum Toxin
Indian Journal of Physical Medicine & RehabilitationWe describe the case of a 70-year-old male sustained a traumatic right-sided sub-dural haemorrhage and underwent decompressive craniotomy for the same.
A Aakhil Nabuhan +3 more
doaj +1 more source
BMC Infectious Diseases, 2019 Background Trimethoprim-sulfamethoxazole (TMP-SMX) is the drug of choice for anti-Pneumocystis jirovecii pneumonia (PcP) prophylaxis in kidney transplant recipients (KTR).
G. V. Ramesh Prasad +7 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Utilizing group-based models to identify adverse event patterns after an intervention
Frontiers in MedicineBackgroundStandard adverse event (AE) monitoring only records whether events occur after the intervention, and not whether these events vary over time.ObjectiveTo test whether there were statistically distinct time-varying trajectories of AE (e.g., “side
Wei Wang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The Labor Market Impact of Immigration in Western Germany in the 1990’s [PDF]
We adopt a general equilibrium approach in order to measure the effects of recent immigration on the Western German labor market, looking at both wage and employment effects.
Francesco D’Amuri +2 more
core +6 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
ADVERSE EFFECTS OF ANTIEPILEPTIC DRUGS
Эпилепсия и пароксизмальные состояния, 2017 Antiepileptic drugs are frequently associated with a risk of adverse effects, which have an impact on the tolerability and success of treatment. Patients who develop intolerable adverse effects have to discontinue treatment early after initiation or to ...
I. Yu. Kovaleva
doaj +1 more source
Minimum Wage with Optimal Income Taxation [PDF]
Minimum wage legislation is a standard policy tool in most countries. However, the overall merits of minimum wage are controversial due to its potential adverse effects on unemployment.
Efraim Sadka, Tomer Blumkin
core