Results 91 to 100 of about 3,542,749 (309)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Isotretinoin and the Kidney: Opportunities and Threats
Clinical, Cosmetic and Investigational Dermatology, 2020 Bahareh Forouzani-Haghighi, Iman Karimzadeh Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranCorrespondence: Iman KarimzadehDepartment of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of
Forouzani-Haghighi B, Karimzadeh I
doaj
Disulfiram-induced psychosis at a therapeutic dose and in clear sensorium: Two case demonstrations
Journal of Mental Health and Human Behaviour, 2019 The literature on disulfiram induced psychosis showed, it was either associated with delirium or preceded by a prescription of a higher dose. We report two cases of psychosis in clear sensorium developing in individuals with alcohol dependence without ...
Abhishek Ghosh +3 more
doaj +1 more source
Capital Controls, Political Institutions, and Economic Growth: A Panel and Cross Country Analysis [PDF]
, 2007 Statistical studies on the effects of capital controls on growth have generally yielded insignificant results. In this paper, we show that capital controls negatively affect growth in authoritarian countries, while growth in democratic countries is ...
Shanker Satyanath, Shanker Satyanath
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Double guide catheter technique for sealing an iatrogenic coronary perforation
Research in Cardiovascular Medicine, 2016 Introduction: Coronary vessel perforation is one of the most feared complications of coronary angioplasty. The treatment of this complication relies mostly on the implantation of covered stents.
Miguel Rodriguez-Santamarta +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Common and less common adverse effects of antihypertensives: a general practitioner’s perspective
South African Family Practice, 2012 No abstract available.
Y. Trinder
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
, 2014 Citation: 'adverse effect' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.AT06809 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source