Results 11 to 20 of about 6,670,507 (363)

Immune-related adverse events and the balancing act of immunotherapy

Nature Communications, 2022
The benefit from immune checkpoint inhibitors is tempered by immunologic toxicities, which involve diverse organs, have varying biology, onset time, and severity. Herein, we identify important areas of controversy and open research questions in the field
M. Conroy, J. Naidoo
semanticscholar   +1 more source

META-INSTI: metabolic adverse events following integrase strand transfer inhibitor administration in spontaneous adverse event reports [PDF]

, 2023
Background: Metabolic effects of integrase strand transfer inhibitors (INSTIs) have been reported. The FDA Adverse Event Reporting System (FAERS) is a publicly available database that captures spontaneously reported adverse events.
Lara Fakhouri, Spencer E Harpe, Milena M Murray   +2 more
core   +1 more source

Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults

Vaccine, 2022
Introduction In 2020, prior to COVID-19 vaccine rollout, the Brighton Collaboration created a priority list, endorsed by the World Health Organization, of potential adverse events relevant to COVID-19 vaccines.
Joseph B Fraiman, J. Erviti, Mark Jones, S. Greenland, P. Whelan, R. Kaplan, P. Doshi   +6 more
semanticscholar   +1 more source

Adverse Events in Pediatric Inpatients: The Japan Adverse Event Study

Journal of Patient Safety, 2023
Objectives Adverse events (AEs) represent an important cause of morbidity and mortality for pediatric inpatients; however, reports on their epidemiology in pediatrics, especially outside Western countries, are scarce. We investigated the incidence and nature of AEs in pediatric inpatients in Japan.
Sakuma, Mio, Ohta, Yoshinori, Takeuchi, Jiro, Yuza, Yuki, Ida, Hiroyuki, Bates, David W., Morimoto, Takeshi   +6 more
openaire   +2 more sources

Adverse events associated with JAK inhibitors in 126,815 reports from the WHO pharmacovigilance database

Scientific Reports, 2022
Increasing number of Janus kinase (JAK) inhibitors have been approved for chronic haematopoietic neoplasms and inflammatory/autoimmune diseases.
L. Hoisnard, B. Lebrun-Vignes, S. Maury, M. Mahévas, K. El Karoui, L. Roy, Anissa Zarour, M. Michel, J. Cohen, A. Amiot, P. Claudepierre, P. Wolkenstein, P. Grimbert, Emilie Sbidian   +13 more
semanticscholar   +1 more source

Gastrointestinal adverse events associated with semaglutide: A pharmacovigilance study based on FDA adverse event reporting system

Frontiers in Public Health, 2022
Background Semaglutide was approved for treatment of type 2 diabetes mellitus (T2DM) and chronic weight management in obesity or overweight adults. However, real-world data regarding its long-term gastrointestinal safety and tolerability in large sample ...
Yamin Shu, Xucheng He, Pan Wu, Yanxin Liu, Yufeng Ding, Qilin Zhang   +5 more
semanticscholar   +1 more source

Surveillance for Adverse Events After COVID-19 mRNA Vaccination.

Journal of the American Medical Association (JAMA), 2021
Importance Safety surveillance of vaccines against COVID-19 is critical to ensure safety, maintain trust, and inform policy. Objectives To monitor 23 serious outcomes weekly, using comprehensive health records on a diverse population. Design, Setting,
N. Klein, N. Lewis, Kristin Goddard, B. Fireman, O. Zerbo, K. Hanson, J. Donahue, E. Kharbanda, A. Naleway, J. Nelson, Stanley Xu, W. K. Yih, J. Glanz, Joshua T. B. Williams, S. Hambidge, Bruno J. Lewin, T. Shimabukuro, F. Destefano, Eric S. Weintraub   +18 more
semanticscholar   +1 more source

Overlap between adverse events (AEs) and serious adverse events (SAEs): a case study of a phase III cancer clinical trial

Trials, 2020
Background Safety data is required to be collected in all clinical trials and can be separated into two types of data, adverse events and serious adverse events.
Elizabeth C. James, David Dunn, Adrian D. Cook, Andrew R. Clamp, Matthew R. Sydes   +4 more
doaj   +1 more source

Public Health Surveillance for Adverse Events Following Covid-19 Vaccination in Africa: Rare Adverse Events and Fatal Cases Following COVID-19 Vaccination in Africa [PDF]

, 2022
Background: The death toll and economic disaster caused by SARS-CoV-2/ COVID-19 is still on the rise globally and in Africa with a case fatality ratio (CFR), 2.58 from 220,958 deaths out of 8,556,890 cases recorded across the continent as of 14th ...
Elelu, Nusirat, Mosbah, Rasha, Fasina, Folorunsho, Razouqi, Youssef, Salako, Babatunde, Mhgoob, Zuhal, Ntirenganya, Lazare, Ajayi, Tunde, Elnadi, Hager, Odetokun, Ismail, Eyedo, Joseph, Awiagah, Kwame, Gachara, George, Nyandwi, Jean, Maisara, Aala, Abioye, Ajibola, Mohamed, Yusuf, Mohamud, Wright, Kikelomo, Saibu, Morounke, Anjorin, AbdulAzeez   +19 more
core   +1 more source

Regular treatment with formoterol for chronic asthma: serious adverse events [PDF]

, 2012
Epidemiological evidence has suggested a link between beta(2)-agonists and increases in asthma mortality. There has been much debate about possible causal links for this association, and whether regular (daily) long-acting beta2-agonists are safe ...
Christopher J Cates, Cates, MJ, Matthew J Cates, Cates, CJ   +3 more
core   +1 more source