Results 61 to 70 of about 5,575,329 (338)

Pseudoprogression as an adverse event of glioblastoma therapy [PDF]

Cancer Medicine, 2017
AbstractWe explored predictive factors of pseudoprogression (PsP) and its impact on prognosis in a retrospective series of uniformly treated glioblastoma patients. Patients were classified as having PsP, early progression (eP) or neither (nP). We examined potential associations with clinical, molecular, and basal imaging characteristics and compared ...
Balaña, Carmen, Capellades, Jaume, Pineda, Estela, Estival, Anna, Puig, Josep, Domènech, Sira, Verger, Eugènia, Pujol Farré, Teresa, Martínez García, Maria, Oleaga Zufiría, Laura, Velarde, Jose Maria, Mesia Barroso, Carlos, Fuentes, Rafael, Marruecos, Jordi, Barco, Sonia del, Villà, Salvador, Carrato, Cristina, Gallego, Oscar, Gil Gil, Miguel, Craven Bartle, Jordi, Alameda, Francesc, GLIOCAT Group   +21 more
openaire   +8 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

ADVERSE EVENTS ASSOCIATED WITH THERAPEUTIC DRY NEEDLING.

International Journal of Sports Physical Therapy, 2020
Background There is a paucity of literature about the adverse events associated with Therapeutic Dry Needling (TDN). Much of the literature surrounding adverse events associated with TDN has been extrapolated from the acupuncture literature.
D. Boyce, H. Wempe, C. Campbell, Spencer Fuehne, E. Zylstra, Grant Smith, C. Wingard, Richard Jones   +7 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Correction to: Serious adverse events and fatal adverse events associated with nivolumab treatment in cancer patients

Journal for ImmunoTherapy of Cancer, 2019
Following publication of the original article [1], the authors reported an error in their listed affiliations.
Bin Zhao, Hong Zhao, Jiaxin Zhao
doaj   +1 more source

Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis.

JAMA Oncology, 2019
Importance Programmed cell death (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors have been increasingly used in cancer therapy. Understanding the treatment-related adverse events of these drugs is critical for clinical practice.
Yucai Wang, Shouhao Zhou, Fang Yang, Xinyue Qi, Xin Wang, X. Guan, Chan Shen, N. Duma, Jesus Vera Aguilera, A. Chintakuntlawar, K. Price, J. Molina, L. Pagliaro, T. Halfdanarson, A. Grothey, S. Markovic, G. Nowakowski, S. Ansell, Michael L. Wang   +18 more
semanticscholar   +1 more source

Association Between Parent Comfort With English and Adverse Events Among Hospitalized Children.

JAMA pediatrics, 2020
Importance Children of parents expressing limited comfort with English (LCE) or limited English proficiency may be at increased risk of adverse events (harms due to medical care).
Alisa Khan, Alisa Khan, H. S. Yin, H. S. Yin, Cindy Brach, Dionne A. Graham, D. Graham, Matthew W Ramotar, David N. Williams, David N. Williams, N. Spector, N. Spector, C. Landrigan, C. Landrigan, C. Landrigan, B. Dreyer, B. Dreyer, Patient   +17 more
semanticscholar   +1 more source

Botulinum Toxin Adverse Events [PDF]

, 2018
Abstract Botulinum toxin acts at the neuromuscular junction (motor plaque) blocking the release and effects of acetylcholine (ACh), a neurotransmitter of both the central nervous system (CNS) and the peripheral nervous system (SNP). By inhibiting the release of acetylcholine, botulinum toxin interferes with the nervous impulse and causes a ...
Pero, Raffaela, Laneri, Sonia, Fico, Giovanna   +2 more
openaire   +4 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source