Results 61 to 70 of about 1,340,339 (303)

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Pharmacovigilance in Vaccines: Importance, Main Aspects, Perspectives, and Challenges—A Narrative Review

Pharmaceuticals
Pharmacovigilance plays a central role in safeguarding public health by continuously monitoring the safety of vaccines, being critical in a climate of vaccine hesitancy, where public trust is paramount.
Katharine Valéria Saraiva Hodel, Bianca Sampaio Dotto Fiuza, Rodrigo Souza Conceição, Augusto Cezar Magalhães Aleluia, Thassila Nogueira Pitanga, Larissa Moraes dos Santos Fonseca, Camila Oliveira Valente, Cintia Silva Minafra-Rezende, Bruna Aparecida Souza Machado   +8 more
doaj   +1 more source

An evolutionary approach to the representation of adverse events [PDF]

, 2009
One way to detect, monitor and prevent adverse events with the help of Information Technology is by using ontologies capable of representing three levels of reality: what is the case, what is believed about reality, and what is represented.
Capolupo, Maria, Ceusters, Werner, De Moor, Georges, Smith, Barry   +3 more
core   +1 more source

Estimating risk when zero events have been observed [PDF]

, 2013
Assessing the risk of complications or adverse events following an intervention presents challenges when they have not yet occurred. Suppose, for instance, a chronic shortage of cardiac telemetry beds has prompted a hospital to implement a new policy ...
Dawson, Jesse, Quigley, John, Revie, Matthew   +2 more
core   +1 more source

Pseudoprogression as an adverse event of glioblastoma therapy [PDF]

Cancer Medicine, 2017
AbstractWe explored predictive factors of pseudoprogression (PsP) and its impact on prognosis in a retrospective series of uniformly treated glioblastoma patients. Patients were classified as having PsP, early progression (eP) or neither (nP). We examined potential associations with clinical, molecular, and basal imaging characteristics and compared ...
Balaña, Carmen, Capellades, Jaume, Pineda, Estela, Estival, Anna, Puig, Josep, Domènech, Sira, Verger, Eugènia, Pujol Farré, Teresa, Martínez García, Maria, Oleaga Zufiría, Laura, Velarde, Jose Maria, Mesia Barroso, Carlos, Fuentes, Rafael, Marruecos, Jordi, Barco, Sonia del, Villà, Salvador, Carrato, Cristina, Gallego, Oscar, Gil Gil, Miguel, Craven Bartle, Jordi, Alameda, Francesc, GLIOCAT Group   +21 more
openaire   +8 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Rofecoxib and cardiovascular adverse events in adjuvant treatment of colorectal cancer [PDF]

, 2007
Background Selective cyclooxygenase inhibitors may retard the progression of cancer, but they have enhanced thrombotic potential. We report on cardiovascular adverse events in patients receiving rofecoxib to reduce rates of recurrence of colorectal ...
Andrew Stanley, Christopher C. McConkey, Claire Iveson, David J. Kerr, Giovannucci E, Janet A. Dunn, Joanne C. Stokes, Justine L. Smith, Michael J. Langman, Oshima M, Patrick Julier, Rachel S.J. Midgley, Ravi Duvvuri, Thun MJ   +13 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

A prospective cohort study comparing the reactogenicity of trivalent influenza vaccine in pregnant and non-pregnant women [PDF]

, 2015
Background: Influenza vaccination during pregnancy can prevent serious illness in expectant mothers and provide protection to newborns; however, historically uptake has been limited due to a number of factors, including safety concerns.
A Legge, AK Regan, AL Naleway, Annette K Regan, C Yuet Sheung Yuen, CA Peschken, Caroline Talbot, Christopher C Blyth, D Carcione, DB Fell, Donna B Mak, EO Kharbanda, Geoffrey Shellam, IH Russo, JD Nordin, JD Nordin, JR Russo, KE Wiley, Lauren Tracey, M Henninger, MJ Bartlett, P Duclos, Paul V Effler, Peter C Richmond, PL Moro, PV Effler, RA Bednarczyk, SE Haberg, SE Taksdal, World Health Organisation   +29 more
core   +2 more sources