The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Why Adverse Selection Need Not Be Adverse [PDF]
, 2015 Restrictions on insurance risk classification can lead to troublesome adverse selection. A simple version of the usual argument is as follows. If insurers cannot charge risk-differentiated premiums, more insurance is bought by higher risks and less ...
Tapadar, Pradip
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Considerations for learning-oriented monitoring and evaluation with Outcome Mapping [PDF]
, 2009 Outcome Mapping (OM) was developed both as a planning and a monitoring tool. And while it has been used successfully for both purposes, this brief focuses on OM as a monitoring and evaluation (M&E) approach.
Ambrose, Kaia
core +1 more source
Laboratory adverse events and discontinuation of therapy according to CD4+ cell count at the start of antiretroviral therapy. [PDF]
, 2014 Few data describe antiretroviral treatment (ART)-related adverse events when treatment is initiated at CD4 cell counts more than 350 cells/μl.
Chadwick, D +31 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Brachial Artery Constriction during Brachial Artery Reactivity Testing Predicts Major Adverse Clinical Outcomes in Women with Suspected Myocardial Ischemia: Results from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study [PDF]
, 2013 Background:Limited brachial artery (BA) flow-mediated dilation during brachial artery reactivity testing (BART) has been linked to increased cardiovascular risk.
Sedlak, TL +4 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Huli yanjiu, 2021 This paper introduced concept and evaluation methods of chronic obstructive pulmonary disease（COPD） related fatigue，analyzed its adverse outcomes，summarized non⁃pharmacological interventions.It aimed at providing references for formulating effective COPD
XIAO Liyun, WU Peixiang, GAO He, XU Cui
doaj
The Relation between Treated Maternal Urinary Tract Infection and Adverse Maternal, Prenatal Outcomes in Pregnant Women of Ardabil, Iran [PDF]
Background and Objective: Urinary tract infection is one of the most common bacterial infections during pregnancy and has also been implicated as a risk factor for adverse maternal and prenatal outcomes.
مرادی, شهلا +5 more
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