Results 101 to 110 of about 3,718,310 (310)

Is antenatal syphilis screening still cost effective in sub-Saharan Africa [PDF]

, 2003
Objectives: To estimate the cost effectiveness of on-site antenatal syphilis screening and treatment in\ud Mwanza, Tanzania. To compare this intervention with other antenatal and child health interventions,\ud specifically the prevention of mother to ...
Weiss, H, Ndeli, L, Changalucha, J, Hays, R, Gumodoka, B, Lisekie, F, Ndeki, L, Watson-Jones, D, Mugeye, K, Mabey, D, Kumaranayake, L, Terris-Prestholt, F, Todd, J, Hayes, R   +13 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Increased Serum Parathyroid Hormone, Osteocalcin and Alkaline Phosphatase Are Associated with a Long-Term Adverse Cardiovascular Outcome after Coronary Artery Bypass Graft Surgery

Diagnostics, 2019
Despite the fact that an association of osteopoenia/osteoporosis with elevated risk of coronary artery calcification (CAC) and coronary atherosclerosis (CA) is well-established, it remains unclear whether bone turnover markers can be employed in long ...
Olga Barbarash, Mikhail Zykov, Vasiliy Kashtalap, Oksana Hryachkova, Alexandr Kokov, Olga Gruzdeva, Irina Shibanova, Anton Kutikhin   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Management of Pregnancy in Women of Advanced Maternal Age: Improving Outcomes for Mother and Baby

International Journal of Women's Health, 2021
Itamar Glick,1 Ela Kadish,2 Misgav Rottenstreich1,3 1Department of Obstetrics & Gynecology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel; 2Faculty of Medicine, Hebrew University of Jerusalem ...
Glick I, Kadish E, Rottenstreich M
doaj  

ROLE OF CARDIAC-ANKLE VASCULAR INDEX IN PREDICTION OF LONG TERM ADVERSE OUTCOMES IN PATIENTS WITH NON ST ELEVATION ACUTE CORONARY SYNDROME

Кардиоваскулярная терапия и профилактика, 2018
Aim. Evaluation of the association of cardiac-ankle vascular index and development of adverse outcomes in patients after non-ST elevation acute coronary syndrome (NSTEACS).Material and methods. To the registry of NSTEACS in 2009.
S. A. Berns, E. A. Schmidt, О. A. Nagirniak, I. I. Zhidkova, М. N. Litvinova, O. L. Barbarash   +5 more
doaj   +1 more source

Material Adverse Change Clauses and Acquisition Dynamics [PDF]

Material-Adverse-Change clauses (MACs) are present in over 90% of acquisition agreements. These clauses are the outcome of extensive negotiation and exhibit substantial cross-sectional variation in the number and types of events that are excluded from ...
Antonio J. Macias, David J. Denis
core  

Baseline characteristics and patient reported outcome data of patients prescribed etanercept: web-based and telephone evaluation [PDF]

, 2011
<p>Background: The anti-TNF inhibitor, etanercept is administered as a once or twice weekly subcutaneous injection for the treatment of rheumatoid arthritis, psoriasis, ankylosing spondylitis, psoriatic arthritis and juvenile idiopathic arthritis ...
Alex McConnachie, Susan Maycock, Pumford, N., McConnachie, A., Neil Pumford, Gordon M Crawford, Wade, A.G., Volker Koscielny, Koscielny, V., Alan G Wade, Crawford, G.M., Maycock, S.   +11 more
core   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source