Results 81 to 90 of about 2,016,996 (294)

Web-based physiotherapy for people affected by multiple sclerosis: a single blind, randomized controlled feasibility study [PDF]

, 2018
Objective: To examine the feasibility of a trial to evaluate web-based physiotherapy compared to a standard home exercise programme in people with multiple sclerosis. Design: Multi-centre, randomized controlled, feasibility study.
Alex McConnachie, Belinda Weller, Berg K, Brazier J, Brennan DM, Cohen J., Curtis L, Elaine H Coulter, Frevel D, Heather Murray, Jennifer Freeman, Khan F, Linda Renfrew, Lorna Paul, Olivia Wu, Paul Mattison, Robert Heggie   +16 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT trial [PDF]

, 2007
<p><b>Background and Purpose:</b> NXY-059 is a free radical-trapping neuroprotectant developed for use in acute ischemic stroke. To facilitate prompt administration of treatment, potentially before neuroimaging, we investigated the ...
Ahlberg, G., Ashwood, T.J., Davalos, A., Davis, S.M., Diener, H.-C., Grotta, J.C., Hardemark, H.-G., Lees, K.R., Lyden, P.D., Rodichok, L., Shuaib, A., Svensson, H.H., Wasiewski, W.W.   +12 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Patient-reported outcomes following flexible sigmoidoscopy screening for colorectal cancer in a demonstration screening programme in the UK [PDF]

, 2012
<p>OBJECTIVES: Flexible sigmoidoscopy (FS) screening for colorectal cancer will be introduced into the National Cancer Screening Programmes in England in 2013.
Atkin, W., Edwards, R., Kralj-Hans, I., Lo, S.H., Power, E., Robb, K.A., Vance, M., Von Wagner, C., Wardle, J.   +8 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Illicit drug use and cerebral microbleeds in stroke and transient ischemic attack patients [PDF]

, 2019
Background: Cerebral microbleeds (CMB) signal cerebral small vessel disease and are associated with ischemic stroke (IS) incidence, recurrence, and complications.
Abbas, Saleh, Aparicio, Hugo, Cajiga-Pena, Fe Maria, Cervantes-Arslanian, Anna, Dam, Katie, Finn, Brandon, Greer, David, Lau, Helena, Nguyen, Thanh, Petrie, Benjamin, Romero, Jose Rafael   +10 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Some diagnostic defects and their causes in emergency cardiac care

Кардиоваскулярная терапия и профилактика, 1970
Aim. To analyze diagnostic defects and to identify objective and subjective factors causing inadequate emergency cardiac medical care (ECMC). Material and methods.
Yu. D. Sergeev, Yu. V. Bisyuk
doaj