Results 1 to 10 of about 3,485,469 (299)

Novel Therapeutic Targets in Liver Fibrosis

Frontiers in Molecular Biosciences, 2021
Liver fibrosis is end-stage liver disease that can be rescued. If irritation continues due to viral infection, schistosomiasis and alcoholism, liver fibrosis can progress to liver cirrhosis and even cancer.
Jinhang Zhang, Qinhui Liu, Jinhan He, Jinhan He, Yanping Li   +4 more
doaj   +1 more source

Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis

Frontiers in Pharmacology, 2021
Background and Purpose: Activation of hepatic stellate cells (HSC) is a central driver of liver fibrosis. 5-lipoxygenase (5-LO) is the key enzyme that catalyzes arachidonic acid into leukotrienes.
Shiyun Pu, Shiyun Pu, Yanping Li, Qinhui Liu, Xu Zhang, Lei Chen, Lei Chen, Rui Li, Rui Li, Jinhang Zhang, Jinhang Zhang, Tong Wu, Tong Wu, Qin Tang, Qin Tang, Xuping Yang, Xuping Yang, Zijing Zhang, Zijing Zhang, Ya Huang, Ya Huang, Jiangying Kuang, Jiangying Kuang, Hong Li, Hong Li, Min Zou, Wei Jiang, Jinhan He, Jinhan He   +28 more
doaj   +1 more source

Safety and effectiveness of all-oral and injectable-containing, bedaquiline-based long treatment regimen for pre-XDR tuberculosis in Vietnam

Frontiers in Pharmacology, 2022
Background: The World health organization (WHO) recently recommended standardized all-oral shorter regimens for rifampicin resistant Tuberculosis (RR-TB).
Thi Mai Phuong Nguyen, Binh Hoa Nguyen, Thi Thanh Thuy Hoang, Hoang Anh Nguyen, Dinh Hoa Vu, Mai Hoa Nguyen, Bao Ngoc Nguyen, Tom Decroo, Viet Nhung Nguyen   +8 more
doaj   +1 more source

Adverse Reactions to Voriconazole [PDF]

Clinical Infectious Diseases, 2004
Voriconazole is a new antifungal agent effective in the treatment of invasive aspergillosis. Interpatient variation in plasma concentrations is considerable--more than 100-fold. We describe 3 patients with diverse manifestations of toxicity (e.g., hallucinations, hypoglycemia, electrolyte disturbance, and pneumonitis) possibly attributable to high ...
Boyd, Aileen E., Modi, Simon, Howard, Susan J., Moore, Caroline B., Keevil, Brian G., Denning, David W.; id_orcid 0000-0001-5626-2251   +5 more
openaire   +2 more sources

Apigenin reduces the suppressive effect of exosomes derived from irritable bowel syndrome patients on the autophagy of human colon epithelial cells by promoting ATG14

World Journal of Surgical Oncology, 2023
Background Inflammatory bowel disease (IBS) is a chronic disorder of the gastrointestinal tract. Exosomes have been involved in various pathological processes including IBS. Apigenin has been reported to suppress inflammatory bowel disease (IBS). However,
Rui Fu, Saiyue Liu, Mingjin Zhu, Jiajie Zhu, Mingxian Chen   +4 more
doaj   +1 more source

Study of prescribing errors of two different prescription systems: pre-printed prescription from historical medication and hand-written prescription [PDF]

Pharmaceutical Sciences Asia, 2022
A retrospective observational study of 1,160 prescriptions with prescribing errors from a large academic hospital in Thailand from 2014 to 2017. The aims of this study are to explore the proportion of prescribing error from pre-printed prescriptions and ...
Nisa Sae-lim, Ploylarp Lertvipapath
doaj   +1 more source

Burden of falls attributable to low bone mineral density among people aged 60 years and over in China from 1990 to 2019

Frontiers in Public Health, 2023
ObjectiveFalls in older people have become a major public health, economic and societal problem. Osteoporosis predisposes older adults to high risk of falls, which were the most common outcome attributable to low bone mineral density (LBMD).
Yali Fu, Yali Fu, Yali Fu, Lei Ba, Lei Ba, Lei Ba, Nianqing Lü, Nianqing Lü, Nianqing Lü, Huafeng Yang, Xin Hong, Jinyi Zhou, Zhiming Sun, Zhiming Sun, Zhiming Sun   +14 more
doaj   +1 more source

Polymer-based dental filling materials placed during pregnancy and risk to the foetus

BMC Oral Health, 2018
Background Tooth-coloured polymer-based dental filling materials are currently the first choice for dental restorative treatment in many countries. However, there are some concerns about their safety.
Trine Lise Lundekvam Berge, Gunvor Bentung Lygre, Stein Atle Lie, Lars Björkman   +3 more
doaj   +1 more source

Adverse drug reactions [PDF]

Clinical Medicine, 2016
Adverse drug reactions (ADRs) remain a challenge in modern healthcare, particularly given the increasing complexity of therapeutics, an ageing population and rising multimorbidity. This article summarises some of the key facts about ADRs and explores aspects relating to their prevention, diagnosis, reporting and management in current clinical practice.
Jamie J, Coleman, Sarah K, Pontefract
openaire   +4 more sources

PEG-Derivatized Dual-Functional Nanomicelles for Improved Cancer Therapy

Frontiers in Pharmacology, 2019
Polymeric micelles have attracted considerable attention for effective delivery of poorly water-soluble cancer drugs. Polyethylene glycol (PEG), which has been approved for human use by the US Food and Drug Administration, is the most commonly used ...
Yanping Li, Ting Zhang, Qinhui Liu, Jinhan He, Jinhan He   +4 more
doaj   +1 more source