Results 31 to 40 of about 42,465 (263)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of a combined exercise program (aerobic and rebound therapy) with two different ratios on some physical and motor fitness indices in intellectually disabled girl

Baltic Journal of Health and Physical Activity, 2019
Background: ‪Individuals with intellectual disability (ID) are mostly neglected and hardly exercised. The purpose of this study was to investigate the effect of a combined program (aerobic and rebound therapy) with two different ratios on some physical ...
AMIR HOSSEIN HAGHIGH, FATEMEH MOHAMMADTAGHIPOOR, MOHAMMADREZA HAMEDINIA, JAVAD HARATI   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Time Course of Oxygen Uptake, Aerobic Capacity and Emg during Two Months of Moderate Interval Endurance Training (A Case Study)

Baltic Journal of Sport and Health Sciences, 2018
Research  background  and  hypothesis. The  low-moderate-intensity  continuous endurance training improved body composition, aerobic capacity and overall health-related parameters in healthy persons.
Sandra Raubaitė, Neringa Baranauskienė, Arvydas Stasiulis   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect of caffeine on aerobic endurance performance

Mexican Journal of Medical Research ICSA, 2016
Supplementation in sport has become very important. The athlete uses ergogenic products or supplements such as caffeine, seeking to improve performance in sports. Therefore, the main objective of this study was to determine the effect of caffeine on aerobic endurance in Mexican professional soccer players.
Muro, Itze Noriega, Parada, Miguel
openaire   +3 more sources

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Prolonged Heat Acclimation and Aerobic Performance in Endurance Trained Athletes [PDF]

Frontiers in Physiology, 2019
Heat acclimation (HA) involves physiological adaptations that directly promote exercise performance in hot environments. However, for endurance-athletes it is unclear if adaptations also improve aerobic capacity and performance in cool conditions, partly because previous randomized controlled trial (RCT) studies have been restricted to short ...
C. Jacob Mikkelsen, Nicklas Junge, Jacob F. Piil, Nathan B. Morris, Laura Oberholzer, Christoph Siebenmann, Christoph Siebenmann, Carsten Lundby, Carsten Lundby, Lars Nybo   +9 more
openaire   +5 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Effects of a strength endurance training program on endurance levels

European Journal of Human Movement, 2010
The purpose of the current study was to determine whether a strength endurance training program of lower limbs isolate can increase endurance levels, both aerobic capacity and aerobic power, in order to adapt the strength training for endurance races. 20
G. Cuadrado, A. M. De Benito, S. Sedano, J. M. Izquierdo, J. C. Redondo, J. C. Granado   +5 more
doaj