Results 51 to 60 of about 42,465 (263)

Blood flow restriction endurance exercise and endurance performance in athletes

Exercise and Quality of Life
The development and advancement of sports training over time have been accompanied by continuous innovations, which significantly contribute to improving athletic performance.
Matevž Arčon, Nejc Črnčič
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Endurance training for judo athletes: Improving anaerobic and aerobic capacity in the high altitude

Journal Sport Area
Background Problems: Judo is a sport that requires aerobic and anaerobic abilities. This is because the scoring in judo matches is different from other martial arts, where athletes will look for absolute 'ippon' points in one match.
Ira Purnamasari, Geraldi Novian, Mona Fiametta Febrianty, Alen Rismayadi   +3 more
doaj   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

A three-arm randomized controlled trial of aerobic and resistance training in women with spinal cord injuries: Effects on physical fitness and pulmonary function

Heliyon
Background: This study aimed to investigate the effects of different volumes of aerobic training (AT) and resistance training (RT) during a concurrent exercise training program on selected indicators of physical fitness and pulmonary function in women ...
Amir Hossein Haghighi, Atefeh Ahmadi, Roya Askari, Hadi Shahrabadi, Jeremy A. Moody, Joshua M. Miller, Filipe Clemente, Paulo Gentil   +7 more
doaj   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Self-Reported Physical Activity and Aerobic Endurance Among Female Students of Pavol Jozef Šafárik University in Košice, Slovakia

Sport i Turystyka
One of the easiest ways to improve everyone’s physical and mental health is to choose appropriate physical activity (PA). Its general decline in recent decades has triggered an increase in civilisation-related diseases. Female college students neglect PA
Agata Horbacz, Mária Majherová, Richard Melichar, Ján Junger   +3 more
doaj   +1 more source

Identification and Evaluation of the Aerobic Capacity of Athletic and Rowing Team Players of Islamabad City (The Capital of Pakistan)

The Sky, 2020
Aerobic capacity is dominant factor of every individual for attaining dominating performance in sports particularly to achieve optimum performance in the endurance sports.
Muhammad Safdar Ali, Pro.Dr. Mohibullaha Khan Marwat, Ghulam Shabbir Anjum   +2 more
doaj   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source