Results 71 to 80 of about 42,465 (263)

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Respiratory muscle training improves aerobic capacity and respiratory muscle strength in youth wrestlers

Frontiers in Physiology
BackgroundRespiratory muscle training (RMT) has shown potential for enhancing athletic performance, but its effectiveness, in youth wrestlers, remains unclear.
Mehmet Ismail Tosun, Erkan Demirkan, Abdurrahim Kaplan, Yasemin Ari Yilmaz, Irem Eker Arici, Michael Favre, Veysi Aslan, Mehmet Kutlu   +7 more
doaj   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

Advanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang   +10 more
wiley   +1 more source

Effects of circuit training method on reactive agility and endurance in table tennis players

Pedagogy of Physical Culture and Sports
Background and Study Aim. Reactive agility and aerobic endurance are crucial physical components for athletes' success in both competitions and training.
Hary Widodo, Tomoliyus, Abdul Alim, Muhammad K. Ansori   +3 more
doaj   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

The Effect of Aerobics Dance and Water Aerobics on Muscle Endurance [PDF]

Proceedings of the 4th International Conference on Sport Science, Health, and Physical Education (ICSSHPE 2019), 2020
Kuston Sultoni, Mustika Fitri, Nurul Fadlillah Indriani   +2 more
openaire   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Effects of blood flow restriction training on aerobic capacity and performance in endurance athletes: a systematic review and meta-analysis

BMC Sports Science, Medicine and Rehabilitation
Background Although blood flow restriction (BFR) training has been increasingly investigated for its potential to enhance aerobic capacity and performance in endurance athletes, its overall effectiveness remains inconclusive.
Zekai Zhang, Xuejiao Gao, Lang Gao
doaj   +1 more source

Effectiveness of Aerobic Training on Cardiopulmonary Function and Quality of Life in Children with Cerebral Palsy: A Single-Blinded Randomized Trial

Journal of Clinical and Biomedical Sciences
Background: Children with cerebral palsy (CP) often experience reduced cardiopulmonary endurance and physical activity levels, which can lead to long-term health complications.
Mukherjee Prathana, Das Partha Ranjan, Pradhan Deepak Kumar, Sahoo Rajesh, Mishra Priyadarshini   +4 more
doaj   +1 more source