Results 91 to 100 of about 40,365 (262)

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

open access: yesAdvanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang   +5 more
wiley   +1 more source

Aerobic response to endurance training in prepubescent children

open access: yesMedicine & Science in Sports & Exercise, 1985
Children and adolescents possess higher weight-related maximum oxygen consumption (VO2max) levels than older individuals. The capacity of prepubescent children to improve aerobic fitness with endurance training is controversial, and reported data have provided conflicting evidence.
openaire   +3 more sources

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

open access: yesAdvanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang   +7 more
wiley   +1 more source

Effects of 8 weeks of aerobic endurance training on functional capacity and metabolic variables in people with type 1 diabetes: A secondary outcome analysis of the ULTRAFLEXI-1 study. [PDF]

open access: yesDiabetes Obes Metab, 2023
Müller A   +12 more
europepmc   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

open access: yesAdvanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun   +12 more
wiley   +1 more source

The effects of short‐term consumption of a Western diet on aerobic exercise performance in bank voles with inherently distinct metabolic rates

open access: yesExperimental Physiology
Because obesity and related diseases are partly attributed to unrestricted consumption of a high‐fat, high‐sugar Western diet (WD), several studies have examined its adverse effects on health and physical fitness.
Alaa Hseiky   +2 more
doaj   +1 more source

The Impact of Targeted Soccer Training Interventions on YO–YO Intermittent Recovery Test Performance in University-Level Soccer Players

open access: yesPhysical Education Theory and Methodology
Background. Soccer demands high endurance, speed, and aerobic capacity, making fitness a key performance factor. The Yo-Yo Intermittent Recovery Test Level 1 (YYIR1) is a valid field test to assess these attributes in soccer players. Objectives.
Gopal Chandra Saha   +7 more
doaj   +1 more source

The effect of aerobic endurance exercise on changes in heat shock protein 60 and insulin resistance in mice with type 2 diabetes

open access: yesFiyz̤, 2022
Background: Heat shock protein 60 (HSP60) is considered as an indicator of mitochondrial stress and plays a role in modulating mitochondrial dysfunction.
Mehrzad Shabani   +3 more
doaj  

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