Results 81 to 90 of about 42,465 (263)

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

Advanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu   +11 more
wiley   +1 more source

The Importance of Physical Fitness Parameters in Rhythmic Gymnastics: A Scoping Review

Sports
This scoping review presents an overview of physical fitness parameters in rhythmic gymnastics as well as the association of fitness with gymnasts’ performance, competitive level, and age. PubMed, Scopus, and Sport Discus databases were searched.
Vasiliki Gaspari, Gregory C. Bogdanis, Ioli Panidi, Andreas Konrad, Gerasimos Terzis, Anastasia Donti, Olyvia Donti   +6 more
doaj   +1 more source

Follow-up of health-related physical fitness elements in mild intellectual disability for three years: a sex comparison [PDF]

PeerJ
Children with mild intellectual disability (MID) have significant limitations in both intellectual functioning and cognitive, social, and motor skill behaviors. Understanding the development of physical fitness in boys and girls with MID, and identifying
Murat Ergin, Çalık Veli Koçak, Berkan Bozdağ, Hüseyin Gazi Sönmez, Mustafa Karahan, Umut Canli, Peter Bartik, Peter Sagat, Jason Perez, Pablo Prieto-González   +9 more
doaj   +2 more sources

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

ANTHROPOLOGY DIMENSIONS AS INDEPENDENT AEROBIC ENDURANCE

Sport Mont, 2009
Endurance as human capability is treated in two ways. Some authors define it as mobility capability, while others deny this theory. The denying of this theory lies in attitude that endurance is saturated with psychological factors (motivation) and cardio- vascular factors as well and is often identified with aero power, typical dimension of fun ...
Ratko Pavlović, Aleksandar Raković
openaire   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

The Impact of Multiple Dimensions of Socioeconomic Status on Physical Functioning Across the Life Course

Gerontology and Geriatric Medicine, 2018
Objective: We used the Physical Performance Across the LifeSpan Study to investigate the relationships of multiple indicators of socioeconomic status (SES), both in early life and late life, with physical function.
Grace A. Noppert PhD, Candace S. Brown PhD, Marianne Chanti-Ketterl PhD, Katherine S. Hall PhD, L. Kristin Newby MD, Harvey Jay Cohen MD, Miriam C. Morey PhD   +6 more
doaj   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Aerobic response to endurance training in prepubescent children

Medicine & Science in Sports & Exercise, 1985
Children and adolescents possess higher weight-related maximum oxygen consumption (VO2max) levels than older individuals. The capacity of prepubescent children to improve aerobic fitness with endurance training is controversial, and reported data have provided conflicting evidence.
openaire   +3 more sources