Results 91 to 100 of about 300,349 (305)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

The Effects of Aerobic Exercise on NF-κB and TNF-α in Lung Tissue of Male Rat

Novelty in Biomedicine, 2015
Background:Regular aerobic exercise improves theBackground: Regular aerobic exercise improves the inflammatory status in different lung diseases. However, the effects of long-term aerobic exercise on the lung response have not been investigated.
Mohamad Fashi, Hamid Agha-Alinejad, Hasan Asilian Mahabadi, Batul Rezaei, Behzad Behzad Pakrad, Sajad Rezaei   +5 more
doaj  

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Manfaat Latihan Olahraga Aerobik Terhadap Kebugaran Fisik Manusia [PDF]

, 2015
: Aerobic exercise is a kind of exercise systematically by increasing the load gradually and continuously using energy derived from the combustion using oxygen, and takes oxygen without causing fatigue.
Palar, C. M. (Chrisly), Ticoalu, S. H. (Shane), Wongkar, D. (Djon)   +2 more
core  

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Effectivenes of Aerobic and Yoga Exercise to Increase Cardiorespiration Stamina in Carier Women [PDF]

, 2009
Introduction : Cardiorespiratory endurance is one of the components of fitness. Cardiorespiratory endurance is considered to have relation with health because the low grade of fitness connected to high risk of immature death especially cardiovascular ...
Arunia, I. (Ida), Qur\u27aniati, N. (Nuzul), Yunitasari, E. (Esti)   +2 more
core  

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

Effect of Respiratory Muscle Exercises Combined with Step Aerobic Exercise on Respiratory Functions

Research in Sport Education and Sciences
The purpose of the study is to compare the effects of equipment-based respiratory muscle exercises administered at different times on the respiratory functions of sedentary women performing step aerobic exercise.
Zait Burak Aktuğ, Zeynep Kutlu, Serkan İbiş   +2 more
doaj   +1 more source

Effectiveness of aerobic exercise for adults living with HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol [PDF]

, 2016
Background: People with HIV are living longer with the health-related consequences of HIV, multi-morbidity, and aging. Exercise is a key strategy that may improve or sustain health for people living with HIV.
Anne-Marie Tynan, Kelly K. O’Brien, Richard H. Glazier, Stephanie A. Nixon   +3 more
core   +2 more sources

Aerobic Exercise and Endothelium

Manual Therapy, Posturology & Rehabilitation Journal, 2018
Background: A few years ago, it was believed that the endothelium was just a membrane separating blood from the outermost layers of blood vessels. However, it has now become recognized as a mediator of vasoconstricting and vasodilatory substances, regulating vessel tone through the information received.
Allan Di Giaimo D’Almeida, Roberta Luksevicius Rica, Alexandre Lopes Evangelista, Ariana A. Silva, Andrey Jorge Serra, Eliane F. Gama, Danilo Sales Bocalini   +6 more
openaire   +2 more sources