Results 81 to 90 of about 132,769 (300)

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Comparison of 12-Week Fitness Protocols Following Bariatric Surgery: Aerobic Exercise Versus Aerobic Exercise and Progressive Resistance

, 2021
Background Successful bariatric surgery outcomes are better maintained with an exercise program. This pilot study compared the effects on short-term functional capacity and body composition of 2 post-bariatric surgery home-based programs: aerobic ...
YUMUK, Volkan Demirhan, In, Gozde, Al, Muzaffer, Zengin, Kagan, Alptekin, Hasan Kerem, TAŞKIN, Halit Eren, İKİTİMUR, Barış   +6 more
core   +1 more source

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

Effect of aerobic exercise on echocardiographic epicardial adipose tissue thickness in overweight individuals

, 2018
Kalyana Chakravarthy Bairapareddy,1 Arun G Maiya,1 Padma Kumar,2 Krishnananda Nayak,3 Vasudeva Guddattu,4 Vidya Nayak3 1Department of Physiotherapy, SOAHS, Manipal Academy of Higher Education, Manipal, India; 2Department of Cardiology, Kasturba Medical ...
Maiya AG, Guddattu V, Nayak V, Bairapareddy KC, Nayak K, Kumar P   +5 more
core  

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

The Effects of Aerobic Exercise on NF-κB and TNF-α in Lung Tissue of Male Rat

Novelty in Biomedicine, 2015
Background:Regular aerobic exercise improves theBackground: Regular aerobic exercise improves the inflammatory status in different lung diseases. However, the effects of long-term aerobic exercise on the lung response have not been investigated.
Mohamad Fashi, Hamid Agha-Alinejad, Hasan Asilian Mahabadi, Batul Rezaei, Behzad Behzad Pakrad, Sajad Rezaei   +5 more
doaj  

Adherence of older women with strength training and aerobic exercise

, 2014
Alexandra Miranda Assumpção Picorelli, Daniele Sirineu Pereira, Diogo Carvalho Felício, Daniela Maria Dos Anjos, Danielle Aparecida Gomes Pereira, Rosângela Corrêa Dias, Marcella Guimarães Assis, Leani Souza M ...
Pereira DS, Felício DC, Pereira DAG, Pereira LSM, Dias RC, Picorelli AMA, Assis MG, Anjos DMC   +7 more
core  

MetalCenter‐Dependent Selectivity Divergence in MN4 Single‐Atom Catalysts for Aerobic HMF Oxidation

Advanced Science, EarlyView.
Two single‐atom catalysts with M‐N4 configurations (FeN4 and CoN4) were developed for selective HMF oxidation. FeN4 achieves 93.9% selectivity toward FFCA via superoxide anions (O2•−), while CoN4 preferentially produces FDCA through hydroxyl radicals (•OH). DFT calculations reveal that distinct adsorption energies and charge redistribution at the metal
Haoyu Wang, Zhilong Ye, Weihao Wang, Zhi Hu, Qing Tian, Jie Gao, Lianbing Zhang   +6 more
wiley   +1 more source

The Universal Prescription for Parkinson’s Disease: Exercise

Journal of Parkinson’s Disease, 2020
Over the past two decades, aerobic exercise has emerged as a mainstream recommendation to aid in treating Parkinson’s disease (PD). Despite the acknowledgement of the benefits of exercise for people with PD (PwPD), frequently, exercise recommendations ...
Jay L. Alberts, Anson B. Rosenfeldt
doaj   +1 more source