Results 51 to 60 of about 111,400 (297)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Photocatalytic Aerobic Oxidation of Biomass-Derived 5-HMF to DFF over MIL-53(Fe)/g-C₃N₄ Composite

Molecules, 2022
A MIL-53(Fe)/g-C3N4 heterogeneous composite was synthesized and applied in photocatalytic oxidation of 5-hydroxymethylfurfural (5-HMF) to 2,5-diformylfuran (DFF).
Danyao Huang, Hao Wang, Ying Wu
doaj   +1 more source

Novel Ca-doped CePO4 supported ruthenium catalyst with superior catalytic performance for aerobic oxidation of alcohols

, 2011
Novel Ca-doped CePO4 Supported Ruthenium Catalyst with Superior Catalytic Performance for Aerobic Oxidation of AlcoholsCa-doped cerium phosphate (CeCaPO4) has been newly developed and successfully used as catalyst support with superior ion-exchanged ...
张涛, 王军虎, Wang, Junhu, Zhang, Yanjie, Zhang, Tao   +4 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

A Bio-Inspired Lanthanum-Ortho Quinone Catalyst for Aerobic Oxidation of Alcohol

, 2020
Oxidation reactions are fundamental transformations in organic synthesis and chemical industry. With oxygen or air as terminal oxidant, aerobic oxidation catalysis provides the most sustainable and economic oxidation processes.
Sanzhong, Luo, Ruipu, Zhang, Ming-Tian, Zhang, Long, Zhang   +3 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

13C NMR study of the effect of aerobic treatment of olive mill wastewater (OMW) on its lipid-free content [PDF]

, 2008
Olive mill wastewater was treated by an aerobic bio-process at different values of pH (with or without addition of lime), for 45 days on a laboratory scale, to evaluate the reduction of the organic load.
Hafidi, Mohamed, Revel, J.C., Pinelli, Eric, Merlina, Georges, El Hajjouji, Houda, Winterton, Peter, Revel, Jean-Claude   +6 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Effects of Heat and Hypoxia Training on the Fat Oxidation Capacity of Competitive Athletes

European Journal of Sport Science
This study aimed to evaluate the impact of a four‐week heat and hypoxia training on the fat oxidation capacity of competitive athletes. Eight elite male modern pentathlon athletes completed a four‐week aerobic endurance training program in three ...
Zhizhong Geng, Xiaameng Wu, Jinhao Wang, Guohuan Cao, Chenhao Tan, Longji Li, Jun Qiu   +6 more
doaj   +1 more source