Results 61 to 70 of about 78,806 (255)

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Estabilidade aeróbica de silagens de capim-elefante (Pennisetum purpureum, Schum) emurchecido e tratado com inoculante microbiano Aerobic stability of wilted grass silages (Pennisetum Purpureum, Schum.) treated with microbial inoculant

Revista Brasileira de Zootecnia, 2002
Para avaliar o efeito de um inoculante microbiano sobre a estabilidade aeróbica de silagens de capim-elefante (Pennisetum purpureum, Schum) pré-seco, foi conduzido um experimento na UNESP, Campus de Jaboticabal.
Adriana Guim, Pedro de Andrade, Ruben Pablo Iturrino-Schocken, Gumercindo Loriano Franco, Ana Cláudia Ruggieri, Euclides Braga Malheiros   +5 more
doaj   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Effects of Three Different Additives and Two Different Bulk Densities on Maize Silage Characteristics, Temperature Profiles, CO2 and O2–Dynamics in Small Scale Silos during Aerobic Exposure

Applied Sciences, 2017
Silage quality and aerobic stability are sometimes insufficient. If management requirements are not met, or to improve silage quality, additives are often used.
Kerstin Helena Jungbluth, Manfred Trimborn, Gerd-Christian Maack, Wolfgang Büscher, Menghua Li, Hong Cheng, Qiang Cheng, Yurui Sun   +7 more
doaj   +1 more source

Importance of aerobic stability in silages

, 2013
Aerobic stability is a term that indicates the length of the time that silage remains cool and does not spoil after it is exposed to air. Therefore, rapid removal of air from forage mass and prevention of air infiltration into the silage during storage and feed out are the important factors that determine the duration of the silage aerobic stability ...
Ivetić, Aleksandra, Djordjević, Nenad, Radin, Dragoslava, Stojić, Petar, Grubić, Goran, Stojanović, Bojan   +5 more
openaire   +1 more source

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Silagens de grãos de milho puro e com adição de grãos de soja, de girassol ou uréia Quality of corn grain silage added with soybean, sunflower or urea

Pesquisa Agropecuária Brasileira, 2008
O objetivo deste trabalho foi avaliar a composição química e a estabilidade em aerobiose de silagens de grãos de milho, ensilados com adição de soja crua, girassol ou uréia. Em delineamento inteiramente casualizado, com quatro repetições, foram avaliados
Clóves Cabreira Jobim, Lauzimery Lombardi, Francisco Assis Fonseca de Macedo, Antonio Ferriani Branco   +3 more
doaj   +1 more source

Characterization and modelling of aerobic sludge stabilization

, 2021
Bu çalışmada, aerobik koşullardaki biyolojik çamur stabilizasyonunu karakterize etmek için deney ve modelleme çalışmaları yürütülmüştür. Bu kapsamda, içsel solunum ve mikrobiyal aktivitenin aerobik stabilizasyon prosesindeki rolü araştırılmıştır. Ayrıca, aktif çamur prosesi çamur bekletme süresinin (ÇBS) stabilizasyon prosesi üzerine olan etkisi ...
openaire   +1 more source