Results 71 to 80 of about 35,333 (231)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Self-starting Simulation of a Hypersonic Inlet with Variable Free Stream Condition
Journal of Applied Fluid Mechanics, 2020 The flow structure transition of a hypersonic inlet from unstart to start during accelerating trajectory is studied by numerical simulation. The results of pressure distribution along the inlet wall, mass flow rate, total pressure recovery coefficient ...
J. Wu, A. Y. Yu, Y. Y. He, J. J. Le
doaj
Bio-Inspired Aerodynamic Noise Control: A Bibliographic Review
Applied Sciences, 2019 It is well-known that many species of owl have the unique ability to fly silently, which can be attributed to their distinctive and special feather adaptations.
Yong Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Experimental and Numerical Research on End-Wall Flow Mechanism of High-Loading Tandem Stators
Applied SciencesTandem blades have been recognized for their potential to enhance the loading capacity of compressors. However, tandem stators currently do not exhibit advantages due to insufficient understanding of the complex end-wall flow mechanisms. To address this,
Chuanhai Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Optimization of refueling docking trajectory for multi-UAV formation
Xibei Gongye Daxue XuebaoAiming at the optimization of autonomous docking trajectory of unmanned receiver in the in-flight refueling, a high-precision computational fluid dynamics method was used to calculate the dangerous area behind the refueling aircraft as the obstacle in ...
WANG Yuyan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
MachinesThe variable camber morphing wing has the potential to achieve improved flight performance across different flight conditions by changing its geometry according to changing flight conditions.
Yu Zhang +6 more
doaj +1 more source