Results 101 to 110 of about 10,509 (314)

Small Wind Turbine Starting Behaviour [PDF]

, 2012
Small wind turbines that operate in low-wind environments are prone to suffer performance degradation as they often fail to accelerate to a steady, power-producing condition. The behaviour during this process is called “starting behaviour” and it is the
WORASINCHAI, SUPAKIT
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Aerodynamic and Stealth Integrated Design of DSI Inlet by Surrogate-Based Multi-Objective Optimization with EHVI Infill Criterion

Xibei Gongye Daxue Xuebao, 2019
To deal with the problem of aerodynamic and stealth integrated optimization of DSI inlet, a multi-objective optimization study on aerodynamic and stealth of the DSI inlet is carry out which based on the deformation of the three-dimensional compression ...

doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

DEFINITION OF AERODYNAMIC CHARACTERISTICS OF THE PROFILE UNDER THE DRAG POLAR OF THE FINITE WING

Научный вестник МГТУ ГА, 2016
The numerical method of calculation of aerodynamic characteristics of a profile is stated on the basis of the experiment of aerodynamic characteristics of a rectangular wing of a final lengthening.
B. L. Artamonov
doaj  

Transpiration Cooling Using Liquid Water

, 2007
At the Space Launcher System Analysis (SART) department of DLR-Cologne, a hypersonic spaceplane for passenger transportation is being investigated. A major challenge is the aerodynamic heating of the vehicle.
Ali Gülhan, Esser, Burkard, Martin Sippel, Gülhan, Ali, Arnold van Foreest, Kees Sudmeijer, van Foreest, Arnold, Boudewijn Ambrosius, Ambrosius, Boudewijn, Burkard Esser, Sippel, Martin, Sudmeijer, Kees   +11 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Efficient polar optimization of transport aircraft in transonic RANS flow using adjoint gradient based approach

, 2012
A major design requirement for transport aircraft is efficient cruise flight in the transonic region. From the aerodynamic viewpoint, this is achieved by favorable lift-to-drag ratio of the aircraft, both at the main design point and at off-design ...
Brezillon, Joel, Ilic, Caslav, Widhalm, Markus   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Investigation on Adjoint Based Gradient Computations for Realistic 3d Aero-Optimization

, 2010
A discrete adjoint method for e ciently computing gradients for aerodynamic shape op- timizations is presented. The chain itself involves an unstructured mesh Reynolds-Averaged Navier-Stokes solver, and is suitable for the optimization of complex ...
Brezillon, Joel, Caslav, Ilic, Leicht, Tobias, Widhalm, Markus   +3 more
core