Results 91 to 100 of about 10,509 (314)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Research on the Calculation Method of Propeller 1P Loads Based on the Blade Element Momentum Theory
AerospaceAircraft propellers produce relatively large in-plane loads, called propeller 1P loads, during maneuvers such as turning, diving, and lifting, and these loads can negatively affect the flight and control of the aircraft. In order to study the change rule
Wenhui Yan +3 more
doaj +1 more source
Unsteady aerodynamic calculations of flappping wing motion [PDF]
, 2007 Bu tez çırpan kanat hareketinin havada asılı kalma modunu inceleyerek gelecektekimikro hava araçları uygulamalarına ısık olmayı amaçlamıstır. Bu çalısmada, düsükReynolds sayısında kanat kesitinin sekli, kalınlığı, kambur dağılımı gibi geometricparametrelerin ve bunların yanında çırpan kanat hareketinin aerodinamik kuvvetkatsayılarının ve girdap olusum ...
openaire +1 more source
Computational Analysis of the Flow Around an Exposed Wheel [PDF]
, 2010 This thesis presents an investigation of RANS and LES models for the isolated rotating exposed wheel with moving ground with the aim of analyzing the flow behavior and comparing the results in cost/quality context. This is motivated by general demand for
Takeuchi, S.
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Effects of turbulence modelling on the analysis and optimisation of high-lift configurations [PDF]
, 2011 Due to the significant effects on the performance and competitiveness of aircraft, high lift devices are of extreme importance in aircraft design. The flow physics of high lift devices is so complex, that traditional one pass and multi-pass design ...
Guo, Chuanliang.
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Aerodynamic study of a ship sail including calculation of its shape [PDF]
, 2020 This project consists on the calculation of the shape of a ship sail under the load of the wind in downwind conditions, as well as the aerodynamic study and calculation of aerodynamic forces and coefficients through CFD simulations using the OpenFoam ...
Amer Viñas, Max
core +1 more source
The Development of the SpaceLiner Concept and its Latest Progress
, 2012 A visionary, ultrafast passenger transportation concept, proposed as the SpaceLiner, is developed by the Space Launcher System Analysis department of the German Aerospace Center DLR.
Kopp, Alexander +2 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source