Results 91 to 100 of about 147,888 (314)

A theoretical study of the aerodynamic characteristics of lifting-body entry vehicles Summary report, Mar. 1965 - Mar. 1966 [PDF]

Aerodynamic characteristics of lifting-body entry ...
Cahn, M. S., Grahame, W. E., Stevens, J. R.   +2 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A summary of NASA data relative to external-store separation characteristics [PDF]

Aerodynamic characteristics of external stores in carriage position and their effect on separation characteristics under various delivery ...
Mckinney, L. W., Polhamus, E. C.
core   +2 more sources

Simulation of Unsteady Aerdynamic Load for Rigid Coaxial Rotor in Forward Flight with Vortex Particle Method [PDF]

, 2017
Co-axial rotor systems are frequently used for high-speed helicopters. Nevertheless, issues related to rotor-head drag, aerodynamic performance and vibration should also be considered. Simulating the unsteady aerodynamic loads for a rigid coaxial rotor,
Barakos, George N., Sun, Yiming, Tan, Jianfeng   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Modeling Approach for the Balanced Gliding Trajectory of a Hypersonic Vehicle with Pneumatic Iteration

Aerospace
This work presents a method for simulating balanced gliding trajectories of high-hypersonic flight vehicles, circumventing the challenges associated with trajectory modeling for these advanced vehicles.
Guoxu Feng, Yang Bai, Yu Liu, Yizhe Wang, Peng Wang   +4 more
doaj   +1 more source

Test of a NASA blunt body with flares in the JPL 20-inch supersonic and 21-inch hypersonic wind tunnels [PDF]

Aerodynamic characteristics of flares mounted on blunt bodies at supersonic and hypersonic ...
Weaver, R. W.
core   +1 more source

Lift distribution in a rectangular jet [PDF]

, 1971
Computer programs predict effect of slipstream-wing flow interaction on aerodynamic characteristics of deflected slipstream and tilt aircraft. One program calculates lift distribution, lift, and drag of wing in wide slipstream. Results permit development
Jameson, A.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source