Results 91 to 100 of about 157,884 (362)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A Modeling Approach for the Balanced Gliding Trajectory of a Hypersonic Vehicle with Pneumatic Iteration

Aerospace
This work presents a method for simulating balanced gliding trajectories of high-hypersonic flight vehicles, circumventing the challenges associated with trajectory modeling for these advanced vehicles.
Guoxu Feng, Yang Bai, Yu Liu, Yizhe Wang, Peng Wang   +4 more
doaj   +1 more source

Entry dynamics of space shuttle orbiter with longitudinal stability and control uncertainties at supersonic and hypersonic speeds [PDF]

A six-degree-of-freedom simulation analysis was conducted to examine the effects of longitudinal static aerodynamic stability and control uncertainties on the performance of the space shuttle orbiter automatic (no manual inputs) entry guidance and ...
Powell, R. W., Stone, H. W.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Optimizing the Aerodynamic Performance of a Duct–Rotor System for Drones: A Comprehensive Study on the Coupled Parameters

Drones
The integrated ducted structure significantly enhances the aerodynamic performance of the duct–rotor system, reducing noise and enhancing rotor safety. However, in the duct–rotor system, the coupled parameters of the rotor and the duct are crucial to its
Wei Wei, Shiyi Wei, Zhifang Ke, Meng Guo, Yongjie Shu, Qingkai Meng, Leilei Jia, Maofeng Zhang, Shurui Han   +8 more
doaj   +1 more source

Choosing the aerodynamic configuration of a subsonic cruise missile

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2019
The paper presents a comparison of two aerodynamic configurations of subsonic cruise missiles, characterized by the use of swept-back and forward-swept wings. The results of wind tunnel tests with the use of an automated measurement system characterizing
M. A. Kovalev, A. N. Nikitin
doaj   +1 more source

Aerodynamic characteristics and genesis of aggregates at Sakurajima Volcano, Japan. [PDF]

Sci Rep, 2022
Vecino MCD, Rossi E, Freret-Lorgeril V, Fries A, Gabellini P, Lemus J, Pollastri S, Poulidis AP, Iguchi M, Bonadonna C.   +9 more
europepmc   +1 more source

Study of aerodynamic technology for VSTOL fighter attack aircraft [PDF]

Vertical short takeoff aircraft capability, supersonic dash capability, and transonic agility were investigated for the development of Fighter/attack aircraft to be accommodated on ships smaller than present aircraft carriers. Topics covered include: (1)
Burhans, W., Jr., Crafta, V. J., Jr., Dannenhoffer, N., Dellamura, F. A., Krepski, R. E.   +4 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source