Results 61 to 70 of about 147,888 (314)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Layout and Rotation Effect on Aerodynamic Performance of Multi-Rotor Ducted Propellers

Drones
Multi-rotor ducted propellers, which integrate the high-efficiency characteristics of ducted propellers with the layout flexibility and safety advantages of distributed propulsion, are extensively utilized in the propulsion systems of low-altitude ...
Zeyu Li, Jianghao Wu, Pengyu Zhang, Lin Wang, Long Chen, Zhengping Zou, Haiying Lin   +6 more
doaj   +1 more source

The Aerodynamic Characteristics of Road Vehicles Overtaking on Bridge Deck under Crosswinds

Advances in Civil Engineering, 2020
The aerodynamic characteristics of road vehicles in windy environments are the prerequisites for the evaluation and prediction of the driving safety and stability.
Ning Chen, Hongxin Sun, Xiuyong Wang, Longwei Zhang   +3 more
doaj   +1 more source

Wind-tunnel investigation of basic aerodynamic characteristics of a supercritical-wing research airplane configuration [PDF]

Transonic pressure tunnel and transonic tunnel tests were performed to determine the aerodynamic characteristics of a 0.087 scale model of a supercritical wing research airplane configuration at Mach numbers from 0.25 to 1.30.
Bartlett, D. W., Re, R. J.
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Theoretical and experimental investigation of supersonic aerodynamic characteristics of a twin-fuselage concept [PDF]

A theoretical and experimental investigation has been conducted to evaluate the fundamental supersonic aerodynamic characteristics of a generic twin-body model at a Mach number of 2.70.
Brentner, K. S., Miller, D. S., Wood, R. M.   +2 more
core   +1 more source

The aerodynamic characteristics of a family of related hovercraft shapes [PDF]

, 1967
The handling qualities of hovercraft indicate the need for a better understanding of the influence of the basic aerodynamic characteristics. This report is the first of a series in which the aerodynamic characteristics of hovercraft shapes are studied
Andrews, E. J.
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Simulation and Analysis of Aerodynamic Characteristics during Parafoil Canopy Curving Process and Application by LBM

Aerospace
A parafoil is a crucial aerodynamic deceleration device used in the field of airdrop. The overall objective of this paper is to study the aerodynamic characteristics of the curving process of the canopy using the lattice Boltzmann method, to verify it ...
Yi Wang, Chunxin Yang
doaj   +1 more source