Results 81 to 90 of about 147,531 (294)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Assessment of aerodynamic performance of V/STOL and STOVL fighter aircraft [PDF]

The aerodynamic performance of V/STOL and STOVL fighter/attack aircraft was assessed. Aerodynamic and propulsion/airframe integration activities are described and small and large scale research programs are considered. Uncertainties affecting aerodynamic
Nelms, W. P.
core   +1 more source

Curved centerline air intake for a gas turbine engine [PDF]

, 1980
An inlet for a gas turbine engine was disposed about a curved centerline for the purpose of accepting intake air that is flowing at an angle to engine centerline and progressively turning that intake airflow along a curved path into alignment with the ...
Ruehr, W. C., Smith, E. B., Younghans, J. L.   +2 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

DEFINITION OF AERODYNAMIC CHARACTERISTICS OF THE PROFILE UNDER THE DRAG POLAR OF THE FINITE WING

Научный вестник МГТУ ГА, 2016
The numerical method of calculation of aerodynamic characteristics of a profile is stated on the basis of the experiment of aerodynamic characteristics of a rectangular wing of a final lengthening.
B. L. Artamonov
doaj  

Development of a nonlinear switching function and its application to static lift characteristics of straight wings [PDF]

A mathematical modeling technique was developed for the lift characteristics of straight wings throughout a very wide angle of attack range. The technique employs a mathematical switching function that facilitates the representation of the nonlinear ...
Hewes, D. E.
core   +1 more source

Lift distribution in a rectangular jet [PDF]

, 1971
Computer programs predict effect of slipstream-wing flow interaction on aerodynamic characteristics of deflected slipstream and tilt aircraft. One program calculates lift distribution, lift, and drag of wing in wide slipstream. Results permit development
Jameson, A.
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Modeling Approach for the Balanced Gliding Trajectory of a Hypersonic Vehicle with Pneumatic Iteration

Aerospace
This work presents a method for simulating balanced gliding trajectories of high-hypersonic flight vehicles, circumventing the challenges associated with trajectory modeling for these advanced vehicles.
Guoxu Feng, Yang Bai, Yu Liu, Yizhe Wang, Peng Wang   +4 more
doaj   +1 more source

Space shuttle plume simulation application. Results and math model [PDF]

Pressure and gauge wind tunnel data from a transonic test of a 0.02 scale model of the space shuttle launch vehicle was analyzed to define the aerodynamic influence of the main propulsion system and solid rocket booster plumes during the transonic ...
Boyle, W., Conine, B.
core   +1 more source