Results 51 to 60 of about 88,513 (307)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Dynamic Behaviour of a Flexible Yacht Sail Plan [PDF]

open access: yes, 2013
• Dynamic fluid structure interaction of a sail plan is modeled in harmonic pitching • Aerodynamic forces oscillations show hysteresis phenomena • Neglecting the structural deformation underestimates the forces oscillations • Both aerodynamic and ...
AUGIER, Benoit   +3 more
core   +5 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Aerodynamic compensation of the modified guided anti-tank missile configuration [PDF]

open access: yesScientific Technical Review, 2014
Existing old generation anti-tank missiles with single shaped-charge warheads have limited applications against modern tanks with explosive reactive armor.
Mandić Slobodan   +3 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Numerical Computations of Transonic Critical AerodynamicBehavior of a Realistic Artillery Projectile

open access: yesAl-Khawarizmi Engineering Journal, 2009
The determination of aerodynamic coefficients by shell designers is a critical step in the development of any projectile design. Of particular interest is the determination of the aerodynamic coefficients at transonic speeds.
Ahmed F. M. Kridi
doaj   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Accurate calculation of aerodynamic coefficients of parafoil airdrop system based on computational fluid dynamic

open access: yesInternational Journal of Advanced Robotic Systems, 2018
Accurate calculation of canopy aerodynamic parameters is a prerequisite for precise modeling of a parafoil airdrop system. This investigation analyses the aerodynamic performance of the canopy in airdrop testing combining the leading-edge incision and ...
Wannan Wu   +5 more
doaj   +1 more source

The aerodynamic effects of wing rotation and a revised quasi-steady model of flapping flight [PDF]

open access: yes, 2002
We used a dynamically scaled model insect to measure the rotational forces produced by a flapping insect wing. A steadily translating wing was rotated at a range of constant angular velocities, and the resulting aerodynamic forces were measured using a ...
Dickinson, Michael H., Sane, Sanjay P.
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

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