Results 91 to 100 of about 12,489,898 (339)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Review of aerodynamic design in the Netherlands [PDF]
Aerodynamic design activities in the Netherlands, which take place mainly at Fokker, the National Aerospace Laboratory (NLR), and Delft University of Technology (TUD), are discussed.
Labrujere, Th. E.
core +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
The aerodynamic design of an advanced rotor airfoil [PDF]
An advanced rotor airfoil, designed utilizing supercritical airfoil technology and advanced design and analysis methodology is described. The airfoil was designed subject to stringent aerodynamic design criteria for improving the performance over the ...
Blackwell, J. A., Jr., Hinson, B. L.
core +1 more source
Simulation of Unsteady Aerdynamic Load for Rigid Coaxial Rotor in Forward Flight with Vortex Particle Method [PDF]
, 2017 Co-axial rotor systems are frequently used for high-speed helicopters. Nevertheless, issues related to rotor-head drag, aerodynamic performance and vibration should also be considered. Simulating the unsteady aerodynamic loads for a rigid coaxial rotor,
Barakos, George N. +2 more
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
AIP Advances, 2018 The experiment of dielectric barrier discharge (DBD) plasma actuator using an asymmetrical electrodes configuration is conducted to investigate optical emission spectroscopy of the plasma discharge at pressures from 0.02 to 0.1 Mpa in air mixed with ...
S. Y. Xu, L. Kang, J. S. Cai, S. J. Tang
doaj +1 more source
Journal of Civil Engineering and Management, 2012 The article discusses experimental investigations of wind effects and use of design codes for solving aerodynamic problems. It provides data regarding wind-tunnel tests conducted on three buildings with poorly streamlined shapes, including: methodology ...
Roman M. Pavlovsky +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Design, fabrication, and test of a composite material wind turbine rotor blade [PDF]
The aerodynamic design, structural design, fabrication, and structural testing is described for a 60 foot long filament wound, fiberglass/epoxy resin matrix wind turbine rotor blade for a 125 foot diameter, 100 kW wind energy conversion system. One blade
Griffee, D. G., Jr. +2 more
core +1 more source